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Infection and Oncology Lab, Division of Pathophysiology, Institute for Genetic Medicine
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The lab investigates how infection with Helicobacter pylori leads to gastric cancer.
AboutAbout the lab
Exploring how H. pylori infection gives rise to gastric cancer
The Infection and Oncology Lab studies the mechanisms by which H. pylori infection triggers gastric cancer.
Among H. pylori strains, those carrying the cagA gene are the ones involved in the development of gastric cancer.
The CagA protein produced by the bacteria is injected into gastric epithelial cells, where it binds to molecules inside the cells and is thought to promote their transformation into cancer cells.
The lab belongs to the Division of Pathophysiology at the Institute for Genetic Medicine, and Associate Professor Kamiya also serves as a faculty member of the institute's affiliated Center for Infection-Associated Cancer.
Key terms
- H. pylori
- A bacterium that colonizes the stomach. Its full name is Helicobacter pylori
- CagA
- A protein produced by H. pylori. It is delivered into stomach cells through the bacterium's injection apparatus
- Epithelial cells
- Cells that cover the outer surface of the body and the inner surfaces of organs such as the stomach and intestines
ResearchResearch themes
H. pylori strains fall broadly into those with the cagA gene and those without, and it is the cagA-positive strains that are involved in the development of gastric cancer. The lab aims to elucidate how infection with cagA-positive H. pylori leads to gastric cancer.
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MembersFaculty
- Associate ProfessorNaoko Kamiya
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ulcer-causing Bacterium (H.Pylori) Crossing Mucus Layer of Stomach” Illustration Credit: Zina Deretsky, National Science Foundation / Public domain (cropped)
- How CagA triggers gastric cancer: “H pylori virulence factors ja” Y_tambe / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Cell Biology Lab): “Vesicular Stomatitis Virus (VSV) particles (orange) found in extracellular space and budding from the plasma membrane of infected cells (teal)” NIAID / CC BY 2.0 (cropped)
- Related lab (Health Chemistry Lab): “Ileum biopsy with lymphoid tissue, intermed. mag” CoRus13 / CC BY-SA 4.0 (cropped)
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