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Bioanalytical Chemistry Lab
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The lab uses molecular imaging to see, diagnose, and control life.
AboutAbout the lab
See, diagnose, control.
The Bioanalytical Chemistry Lab studies molecular imaging, which visualizes specific molecules inside the body.
By seeing and diagnosing life, the lab works to elucidate the causes of disease and to develop methods for early detection and early treatment.
For control, it creates drugs that are activated at specific sites in the body, and methods to freely control compounds inside the body.
Its main tools are nuclear medicine, which uses radioisotopes, and light such as fluorescence and X-rays.
Key terms
- Molecular imaging
- Technology that visualizes where and how much of a specific molecule is present in the body
- PET
- An imaging method that uses a drug labeled with a positron-emitting radioisotope to show the distribution of molecules in the body
- Auger electron
- An electron emitted by some radioisotopes that travels only a very short distance
- Caged compound
- A compound designed to release a substance trapped inside only when it receives a stimulus such as light
NewsLab news
A student received the 2026 Hokkaido Branch Award of the Japanese Society of Nuclear Medicine
Assistant Professor Goto received the Excellent Presentation Award at the 20th Annual Meeting of the Japanese Society of Molecular Imaging
A student received the Excellent Presentation Award at the 16th Annual Meeting of the Society of Women Scientists
A student received the Excellent Presentation Award at the FY2025 Joint Organic Chemistry Seminar of the Faculty of Pharmaceutical Sciences
A student received the Hoshino Award for Excellent Presentation at the 35th Symposium on Biomedical Analytical Sciences
ResearchResearch themes
With two major themes, seeing and diagnosing life and controlling life, the lab conducts research using nuclear medicine and light. It aims to elucidate disease mechanisms and develop new diagnostic and therapeutic methods.
*Illustrative imageNuclear medicine imaging
Using drugs labeled with radioisotopes such as ¹⁸F, the lab visualizes specific molecules in the body with PET and other methods. It examines changes caused by treatment in animal models of cancer and inflammation, aiming to establish methods to evaluate therapeutic effects.
*Illustrative imageFluorescence and photoacoustic imaging
This research visualizes the inside of the body using fluorescent molecules and the sound waves emitted by molecules that absorb light. The lab develops fluorescence imaging agents that can be used for disease diagnosis, and photoacoustic imaging agents that strongly highlight only lesions.
*Illustrative imageUse of alpha particles and Auger electrons
Using radioisotopes that emit alpha particles or Auger electrons, which travel only very short distances, the lab studies cancer therapy that attacks only targeted cells. It is also working to establish methods to stably attach ²¹¹At and ¹⁹¹Pt to drugs.
*Illustrative imageActivating compounds with X-rays
This research uses X-rays, which reach deep inside the body, to activate caged compounds that release bioactive substances in response to a stimulus. The lab develops compounds that act only where X-rays are applied, leading to treatments with fewer side effects.
MembersFaculty
The members of the Bioanalytical Chemistry Lab consist of faculty members, postdoctoral researchers, PhD, master's, and undergraduate students, and secretaries, along with faculty members from the Institute for Chemical Reaction Design and Discovery (ICReDD).As of 2026
- ProfessorMikako Ogawa
- Associate ProfessorNaoya Ieda
- Assistant ProfessorYuto Goto
- Project Assistant ProfessorAkari Mukaimine
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Molecubes SPECT uCT and PET” Adville / CC BY-SA 4.0 (cropped)
- Nuclear medicine imaging: “PET-MIPS anim frame” Jens Langner (http://www.jens-langner.de/) / Public domain (cropped)
- Fluorescence and photoacoustic imaging: “Fluorescence rainbow” Maxim Bilovitskiy / CC BY-SA 4.0 (cropped)
- Use of alpha particles and Auger electrons: “AlphaDecay” Abeissler3 / CC0 (cropped)
- Activating compounds with X-rays: “Dental x-ray tube” Kyle Senior / CC BY-SA 4.0 (cropped)
- Related lab (遺伝子病制御研究所 病態研究部門 ゲノム医生物学分野): “Condensation1” Ascendinglotus2 / CC BY-SA 3.0 (cropped)
- Related lab (RNA生物学研究室): “FISH 13 21” Gregor1976 / Public domain (cropped)
- Related lab (遺伝子病制御研究所 フロンティア研究ユニット 分子細胞生物研究室): “Vesicular Stomatitis Virus (VSV) particles (orange) found in extracellular space and budding from the plasma membrane of infected cells (teal)” NIAID / CC BY 2.0 (cropped)
- Related lab (未来創剤学研究室): “Bovine Pulmonary Artery Endothelial Cells Fluorescent Image 2” Erin Rod / CC BY 4.0 (cropped)
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