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67 labs · 6 student voices
Other departments in Faculty of Medicine ›Faculties at Kyoto University ›
Naoki Watanabe, Professor
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Neural and Cellular Pharmacology (Watanabe Lab) studies molecules at work inside cells by directly observing them one molecule at a time. Cells sense their surroundings and rapidly reorganize their cytoskeleton, which allows them to proliferate, change shape, and migrate. The lab has shown that fluorescent molecules deep inside cells can be observed one molecule at a time, and has investigated how signals inside cells and the actions of drugs are connected at the molecular level. Methods for observing the movement of molecules inside cells only emerged in this century, and the lab is also committed to training researchers who will develop the potential of these methods.
Seishi Ogawa, Professor
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Tumor Biology (Pathology II) studies the mechanisms of diseases, including cancer, from a genetic perspective. Because disease arises from the interaction between inherited genes and the environment, the lab believes it is important to understand its genetic basis and molecular mechanisms. The lab conducts large-scale genetic analysis using next-generation sequencers, as well as functional analysis using mouse models of disease. The lab welcomes graduate students interested in genome analysis, bioinformatics, and molecular biology, regardless of clinical experience in cancer.
Yasuhiro Murakawa, Professor
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The Pathophysiological Biomedicine Lab aims to create new ways of understanding disease and new medical care from the information in the genome, the blueprint of the human body. By combining cutting-edge measurement technologies, informatics, and classical biochemistry, the lab develops original genome analysis technologies and investigates the mechanisms of disease at the levels of genes, molecules, and cells. In collaboration with hospitals and research institutes, the lab builds large-scale data platforms and conducts research focused on the new genes discovered through them.
Ichiro Nakagawa, Professor
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The Microbial Infectious Diseases Lab studies the mechanisms by which pathogenic bacteria cause infectious diseases. The lab examines bacterial genome information to trace how bacteria acquired pathogenicity and how they evolved, and analyzes at the molecular level how bacteria behave inside host cells. The lab's distinguishing feature is a "hybrid approach" that combines information and experiments on both the bacteria and the host, with the aim of establishing new methods of preventing and treating bacterial infections. For graduate students, the professor provides guidance so that they build a foundation as researchers through research that uses diverse methods, from bioinformatics to cell biology.
Hideki Ueno, Professor
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The Immune Cell Biology Lab (Ueno Lab) specializes in research on human immunity. It has become clear that findings from mice do not always apply directly to humans. The lab therefore uses samples from healthy people and patients to study how the human immune system works and how it is disrupted in disease. Using cutting-edge methods such as single-cell analysis, the lab aims to deepen the understanding of disease, discover biomarkers, and develop new treatments. The lab's targets are infectious diseases, vaccines, cancer immunity, autoimmune diseases, and allergies, and among organs it focuses especially on the liver.
Yoko Nishitani, Professor
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Forensic medicine involves death investigation, which determines the cause of death of deceased people, and research aimed at reducing preventable deaths. The department was established in 1899 and performs autopsies of unnatural deaths in Kyoto Prefecture, so students can learn both forensic practice and research. The lab focuses on how external factors such as poisoning, injury, and daily lifestyle habits damage organs. People who did not graduate from a medical school can also enter the master's and doctoral programs.
So Iwata, Professor
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The Molecular Cell Informatics Lab (Iwata Lab) studies the three-dimensional structures of membrane proteins that are involved in disease and are the targets of many drugs. Looked at closely, how the body functions and how diseases arise come down to the “shapes” of molecules and the interactions between them. The lab mainly determines structures by X-ray crystallography. Based on those structures, it also works on computational design of new drugs and simulations of molecular motion. The lab carries out its research in collaboration with a synchrotron facility in the UK and SACLA, Japan's X-ray free-electron laser facility, and welcomes researchers and graduate students who want to work internationally.
Yasuyuki Fujita, Professor
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The Molecular Oncology Lab studies what happens between normal epithelial cells and mutant cells at the very earliest stage of cancer. Using cultured cells and mice that it established on its own, the lab found that “cell competition,” in which normal cells and mutant cells compete for survival, takes place and that mutant cells are removed from the epithelial layer. This shows that normal epithelial tissue has the ability to eliminate mutant cells without involving the immune system, and it may lead to the development of preventive treatments for cancer.
Takashi Shinohara, Professor
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The Molecular Genetics Lab (Shinohara Lab) focuses on spermatogonial stem cells, the source of sperm, and studies the cellular and molecular mechanisms by which an individual passes genetic information to the next generation. Among germ cells, spermatogonial stem cells are the only ones with the ability to keep producing copies of themselves (self-renewal). The lab established a culture method that allows spermatogonial stem cells to be expanded for a long time in vitro, and named these cells GS cells. It aims to apply the knowledge gained to gene modification technology and medicine.
Takashi Hanakawa, Professor
0 student voices
The Integrated Brain Imaging Lab uses noninvasive methods of measuring the brain, such as MRI, to study how information networks in the brain work and what goes wrong in them in psychiatric and neurological disorders. There is still a gap to be bridged between what can be learned by measuring the brain from the outside and existing knowledge from neuroanatomy and neuropathology. The lab aims to develop technologies that capture brain structure and function seamlessly, from the cellular level to the level of the whole brain. It is also developing neuroengineering technologies that act on brain activity, connecting knowledge toward overcoming psychiatric and neurological disorders.
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