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Immune Cell Biology Lab
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A human immunology lab that uses human samples to uncover how the immune system works normally and how it goes wrong.
AboutAbout the lab
Understanding human immunity through human samples.
The Immune Cell Biology Lab (Ueno Lab) specializes in research on human immunity.
It has become clear that findings from mice do not always apply directly to humans. The lab therefore uses samples from healthy people and patients to study how the human immune system works and how it is disrupted in disease.
Using cutting-edge methods such as single-cell analysis, the lab aims to deepen the understanding of disease, discover biomarkers, and develop new treatments.
The lab's targets are infectious diseases, vaccines, cancer immunity, autoimmune diseases, and allergies, and among organs it focuses especially on the liver.
Key terms
- Immune tolerance
- The mechanism that keeps the immune system from reacting to things it should not attack, such as the body's own tissues or food
- Immune checkpoint
- A molecule that puts the brakes on immune activity. Cancer exploits it to escape immune attack
- Follicular helper T cell
- A type of T cell that helps B cells produce antibodies
ResearchResearch themes
The immune system is an essential mechanism that protects the body from pathogens, but when its regulation breaks down, many diseases result. Using samples from healthy people and patients, the lab studies how the "normal" human immune system works, as well as how immunity becomes "abnormal" and fails in disease.
*Illustrative imageHow immunity is regulated in the human liver
In collaboration with transplant surgery, gastroenterology, and other departments, the lab investigates immune tolerance in chronic hepatitis B and how autoimmune diseases arise in the liver.
*Illustrative imageHow immunity is suppressed around tumors
Only a limited number of patients respond to treatment that blocks immune checkpoints. The lab analyzes immune cells in tumor tissue from cancers such as endometrial cancer and hepatocellular carcinoma, and explores ways to strengthen immunity against cancer and to release the immune suppression caused by cancer.
*Illustrative imageHow immune tolerance breaks down in autoimmune diseases
Using tissue, blood, and cerebrospinal fluid from patients with rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and other diseases, the lab identifies the immune cells directly involved in each disease. It aims to lead to new biomarkers and treatments.
*Illustrative imageAllergies in children and follicular helper T cells
Studies in mice have shown that follicular helper T cells play a central role in producing the antibodies that cause allergy. The lab regularly examines blood from children with egg allergy.
MembersFaculty
The members of the Immune Cell Biology Lab (Ueno Lab) consist of faculty members, project researchers, researchers, graduate students, research students, technical assistants, and project staff.As of 2026
- ProfessorHideki Ueno
- Project ProfessorMasato Kubo
- Project ProfessorTakeshi Kono
- Associate ProfessorHiroyuki Yoshitomi
- Program-Specific LecturerCOPPO Roberto
- Assistant ProfessorYuki Masuo
- Program-Specific Assistant ProfessorYoshitaka Honda
- Program-Specific Assistant ProfessorAsako Shimoda
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Follicular helper T (Tfh) and T follicular regulatory (Tfr) cells both act in the germinal center (GC) to regulate the generation of antigen (Ag)-specific antibody-secreting cells” Xie MM and Dent AL / CC BY 4.0 (cropped)
- How immunity is regulated in the human liver: “Hepatitis B virus v2” Created by en:User:GrahamColm. Original uploader was TimVickers at en.wikipedia / Public domain (cropped)
- How immunity is suppressed around tumors: “Mechanisms of suppression by regulatory T cells” Gwilz / CC BY-SA 4.0 (cropped)
- How immune tolerance breaks down in autoimmune diseases: “Axial PSIR MRI of a brain with multiple sclerosis lesions” Article authors: Alice Favaretto, Davide Poggiali, Andrea Lazzarotto, Giuseppe Rolma, Francesco Causin, Paolo Gallo / CC BY 4.0 (cropped)
- Allergies in children and follicular helper T cells: “Food Allergy- Infancy into Adolescence - 2” NIAID / CC BY 2.0 (cropped)
- Related lab (医化学): “Macrophage by NIAID” NIAID / CC BY 2.0 (cropped)
- Related lab (がん免疫応答制御): “Mitochondria 2 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (免疫薬理学): “Prostaglandin F2alpha 3d” Иван / Public domain (cropped)
- Related lab (高次統御システム間
制御): “Mitochondria, mammalian lung - TEM” Louisa Howard / Public domain (cropped)
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