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Tumor Biology (Pathology II) Lab
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A lab that reads genetic changes in cancer from the genome to get at the mechanisms of disease.
AboutAbout the lab
Approaching the true nature of disease through genetic abnormalities in cancer
Tumor Biology (Pathology II) studies the mechanisms of diseases, including cancer, from a genetic perspective.
Because disease arises from the interaction between inherited genes and the environment, the lab believes it is important to understand its genetic basis and molecular mechanisms.
The lab conducts large-scale genetic analysis using next-generation sequencers, as well as functional analysis using mouse models of disease.
The lab welcomes graduate students interested in genome analysis, bioinformatics, and molecular biology, regardless of clinical experience in cancer.
Key terms
- Next-generation sequencer
- A device that rapidly reads the sequences of large amounts of DNA at once.
- Clonal selection
- The process by which, among a group of cells with mutations, those suited to the environment survive and increase in number.
- Neuroendocrine carcinoma
- A cancer arising from cells that have the property of secreting hormones. It occurs in the digestive tract, pancreas, and elsewhere.
ResearchResearch themes
Using genetics, molecular biology, and developmental engineering, the lab aims to elucidate the genetic basis of disease, particularly malignant tumors, and the mechanisms by which disease arises from it. Sequencing technology has greatly expanded information on gene mutations in cancer, but much remains unknown about how those mutations function.
*Illustrative imageHow Populations of Cancer Cells Become Diverse and Evolve
Cancer is a disease caused by diverse populations that have undergone clonal selection. Using genomics and bioinformatics, the lab investigates how cell populations are selected within environments such as the immune system and acquire the characteristics of cancer.
*Illustrative imageGenetic Abnormalities in Gastrointestinal Cancers
Various cancers arise in the digestive organs, including adenocarcinoma, squamous cell carcinoma, and neuroendocrine carcinoma. By comprehensively examining genetic abnormalities using DNA extracted from pathology specimens, the lab aims to clarify the mechanisms of disease and lead to the development of biomarkers and new therapeutic drugs.
MembersFaculty
The members of Tumor Biology consist of faculty, researchers, and graduate students.
- ProfessorSeishi Ogawa
- Associate ProfessorMasahiro Nakagawa
- Program-Specific Associate ProfessorNobuyuki Kakiuchi
- Program-Specific Associate ProfessorAkinori Yoda
- Assistant ProfessorYotaro Ochi
- Assistant ProfessorRyunosuke Saiki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Whole slide image of H&E stained breast tumour tissue” KajsaMollersen / CC BY-SA 4.0 (cropped)
- How Populations of Cancer Cells Become Diverse and Evolve: “Clonal evolution and development of tumor heterogeneity” El-Sayes, Nader, Alyssa Vito, and Karen Mossman. / CC BY 4.0 (cropped)
- Genetic Abnormalities in Gastrointestinal Cancers: “Tissue processing - Tissue sections on slides are stained on an automated stainer” Ed Uthman / CC BY-SA 2.0 (cropped)
- Related lab (Cancer Immune Multicellular System Regulation Lab): “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Medical Chemistry Lab): “Macrophage by NIAID” NIAID / CC BY 2.0 (cropped)
- Related lab (Molecular Genetics Lab): “Brinster Male germline stem cell transplantation” Credd7398 / CC BY-SA 4.0 (cropped)
- Related lab (Cancer Immune Response Regulation Lab): “Mitochondria 2 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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