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Microbial Infectious Diseases Lab
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This lab tackles infectious diseases through the genomes of pathogenic bacteria and their behavior inside cells.
AboutAbout the lab
Approaching infectious diseases from both the bacteria and the host
The Microbial Infectious Diseases Lab studies the mechanisms by which pathogenic bacteria cause infectious diseases.
The lab examines bacterial genome information to trace how bacteria acquired pathogenicity and how they evolved, and analyzes at the molecular level how bacteria behave inside host cells.
The lab's distinguishing feature is a "hybrid approach" that combines information and experiments on both the bacteria and the host, with the aim of establishing new methods of preventing and treating bacterial infections.
For graduate students, the professor provides guidance so that they build a foundation as researchers through research that uses diverse methods, from bioinformatics to cell biology.
Key terms
- Group A Streptococcus
- A bacterium commonly found in the throat and on the skin. It sometimes causes severe, life-threatening infections.
- Autophagy
- A mechanism by which a cell wraps part of its own contents in a membrane and breaks them down. It also works to remove invading bacteria.
- Whole-genome analysis
- Reading and examining the entire DNA sequence of an organism.
NewsLab news
Prof. Nakagawa received the Asakawa Award of the Japanese Society for Bacteriology
Associate Professor Nozawa received the Rokuzo Kobayashi Memorial Award of the Japanese Society for Bacteriology
ResearchResearch themes
The lab studies how pathogenic bacteria, which are also found in the throat and on the skin of healthy people, have evolved together with humans and sometimes cause severe disease. The lab performs whole-genome analysis of thousands of clinical isolates, functional analysis of virulence factors, and analysis of infection mechanisms using cultured cells and mice.
*Illustrative imagePathogenicity of group A Streptococcus
The lab studies the pathogenicity of group A Streptococcus. It works on the structure and function of virulence factors, whole-genome analysis of clinical isolates, and the development of new drugs effective against this bacterium.
*Illustrative imageHow autophagy eliminates bacteria
Autophagy is known to also work to remove bacteria that have invaded cells. The lab studies the molecular mechanisms by which autophagy detects and kills pathogenic bacteria, and how highly virulent bacteria escape it.
*Illustrative imageGenome analysis of various pathogenic bacteria
By combining data from two types of next-generation sequencers, the lab determines and compares the whole-genome sequences of pathogenic bacteria such as Staphylococcus aureus and Streptococcus pneumoniae.
*Illustrative imageNew therapeutic drugs against pathogenic bacteria
As drug-resistant bacteria spread, control methods that can replace antibiotics are needed. In collaboration with a lab at the University of Tokyo, the lab is developing a drug discovery platform that efficiently selects antibodies that bind strongly to bacterial antigens and obtains them quickly and at low cost.
MembersFaculty
Members of the Microbial Infectious Diseases Lab consist of faculty, researchers, specially appointed staff, and doctoral and master's students.
- ProfessorIchiro Nakagawa
- Associate ProfessorTakashi Nozawa
- Assistant ProfessorKazunori Murase
- Assistant ProfessorAtsuko Nozawa
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Staphylococcus aureus VISA 2” Content Providers(s): CDC/ Matthew J. Arduino, DRPH Photo Credit: Janice Haney Carr / Public domain (cropped)
- Pathogenicity of group A Streptococcus: “Streptococcus pyogenes 01” Photo Credit: Content Providers(s) / Public domain (cropped)
- How autophagy eliminates bacteria: “Autophagy in plants” Géraldine Mitou, Hikmet Budak, and Devrim Gozuacik / CC BY 3.0 (cropped)
- Genome analysis of various pathogenic bacteria: “Staphylococcus aureus Gram stain” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- New therapeutic drugs against pathogenic bacteria: “Antibody-drug conjugate” Bioconjugator / CC BY-SA 4.0 (cropped)
- Related lab (医化学): “Macrophage by NIAID” NIAID / CC BY 2.0 (cropped)
- Related lab (高次統御システム間
制御): “Mitochondria, mammalian lung - TEM” Louisa Howard / Public domain (cropped) - Related lab (薬剤学): “Assistant Pharmacist” M Joko Apriyo Putro / CC BY-SA 4.0 (cropped)
- Related lab (臨床神経学): “Iran Brain Bank” Maryam Kamyab / CC BY 4.0 (cropped)
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