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Molecular Cell Informatics Lab
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The lab reveals, at the atomic level, the shapes of membrane proteins that serve as drug targets.

AboutAbout the lab
Understanding life and drugs through the “shapes” of molecules
The Molecular Cell Informatics Lab (Iwata Lab) studies the three-dimensional structures of membrane proteins that are involved in disease and are the targets of many drugs.
Looked at closely, how the body functions and how diseases arise come down to the “shapes” of molecules and the interactions between them.
The lab mainly determines structures by X-ray crystallography. Based on those structures, it also works on computational design of new drugs and simulations of molecular motion.
The lab carries out its research in collaboration with a synchrotron facility in the UK and SACLA, Japan's X-ray free-electron laser facility, and welcomes researchers and graduate students who want to work internationally.
Key terms
- Membrane protein
- A protein embedded in the membrane that surrounds a cell. It receives signals and moves substances in and out of the cell
- X-ray crystallography
- A method of determining how atoms are arranged by shining X-rays on a protein crystal
- GPCR
- A large group of receptors that receive signals from outside the cell and relay them inside. Many drugs target them
NewsLab news
Published in PNAS how receptors select G proteins, based on the structure of the S1P receptor 3
Published in Nat Struct Mol Biol the structure of the ghrelin receptor bound to a drug
Published in Nat Commun how the human vesicular monoamine transporter distinguishes neurotransmitters
Professor So Iwata awarded the Takeda Medical Prize
Published in Nat Struct Mol Biol how hepatitis B virus binds to its infection receptor
ResearchResearch themes
Membrane proteins form the foundation of cellular function, transmitting signals across the membrane, transporting substances, and producing energy, and they are also important as drug targets. The lab aims to deepen understanding of how cells work by determining their three-dimensional structures, and to efficiently search for drug candidates based on those structures.
View More ↗MembersFaculty
The Molecular Cell Informatics Lab (Iwata Lab) consists of faculty members, researchers and technical staff, graduate students, undergraduate students, and administrative office staff.As of 2026
- ProfessorSo Iwata
- Associate ProfessorNorimichi Nomura
- Program-Specific Associate ProfessorHidetsugu Asada
- Program-Specific Associate ProfessorTsuyoshi Imasaki
- Assistant ProfessorMakoto Adachi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Platform for protein crystallography and X-ray scattering” Evgeny Pelevin / CC BY 4.0 (cropped)
- Solving the three-dimensional structures of human membrane proteins: “CSIRO ScienceImage 296 Protein Crystals Use in XRay Crystallography” division, CSIRO / CC BY 3.0 (cropped)
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