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Integrated Biological Processes Lab
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The lab uses genetically modified mice to explore the mechanisms of fertilization and immunity, and the areas where the two overlap.
AboutAbout the lab
Exploring where fertilization and immunity meet.
The Integrated Biological Processes Lab (Kondoh Lab) pursues research on the mechanisms of fertilization, the regulation of inflammatory helper T cells, and work that combines fertilization and immunology.
Much remains unknown about how sperm acquire the ability to fertilize and how inflammatory helper T cells sustain inflammation in tissues. The lab explores the molecular mechanisms behind these processes in the body from a broad perspective.
In particular, the lab creates genetically modified mice to clarify how important target molecules are in the body.
Key terms
- Genetically modified mice
- Mice in which specific genes have been disrupted or added in order to study the functions of those genes
- Capacitation
- The changes sperm undergo until they become able to fertilize an egg
- Lipid rafts
- Small regions in the cell membrane where specific lipids and proteins cluster together
- Helper T cells
- T cells that direct other immune cells and regulate immune responses
ResearchResearch themes
Centered on methods from biochemistry, molecular biology, and immunology, the lab uses genetically modified mice to investigate how important target molecules are in the body.
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MembersFaculty
- ProfessorGen Kondoh
- Assistant ProfessorHitomi Watanabe
- Program-Specific Assistant ProfessorDaiya Ohara
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Spermatozoa-human-1000x” No specific author / Public domain (cropped)
- How sperm acquire the ability to fertilize: “Sperm-egg” 作者不詳 / Public domain (cropped)
- Related lab (再生免疫学分野): “Methicillin-resistant Staph bacteria ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (発生エピゲノム分野): “0300 Flourescence Stained new” OpenStax / CC BY 4.0 (cropped)
- Related lab (生体膜システム分野): “CCR5 chemokine receptor (molecular surface representation) with an illustration of a cell membrane in the background” NIAID / CC BY 2.0 (cropped)
- Related lab (RNAウイルス分野): “Novel Coronavirus SARS-CoV- )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
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