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RNA Virus Lab
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A lab that studies bornaviruses to explore the mechanisms and evolution of life by understanding viruses.

AboutAbout the lab
Understanding viruses to explore life
Every virus multiplies and spreads by skillfully exploiting the machinery of the organism it infects. Understanding viruses leads not only to understanding their pathogenicity and survival strategies, but also to clarifying how life itself works.
Viruses, which infect every kind of organism on Earth, are also thought to have been indispensable partners in our evolution.
The RNA Virus Lab (Tomonaga Lab) takes "understanding viruses to explore life" as its research goal.
Key terms
- RNA virus
- A virus whose genetic information is carried by RNA rather than DNA.
- Endogenous virus
- A viral sequence integrated into an organism's genome as a remnant of a past infection.
- Viral vector
- A virus stripped of its pathogenicity and used as a tool to deliver genes into cells.
- Bornavirus
- An RNA virus that replicates in the cell nucleus. Some can cause fatal encephalitis in humans.
ResearchResearch themes
Using RNA viruses that cause disease in humans as study material, the lab conducts basic research on infectious diseases. It is also advancing analyses of coevolution using endogenous RNA viruses and the development of new viral vectors for gene therapy.
*Illustrative imageReplication and infection mechanisms of bornaviruses
The main research subject is the bornaviruses, a group of viruses whose genetic information is carried by RNA. The lab investigates virus–cell interactions that cannot be seen with other viruses.
*Illustrative imageEndogenous viruses and virus–host coevolution
Using endogenous viruses remaining in organisms' genomes as clues, the lab analyzes the history in which viruses and their hosts have evolved together, and explores the role of viral infection in the evolution of life.
*Illustrative imageNew viral vectors for gene therapy
Based on RNA viruses, the lab is developing new viral vectors that can be used for gene therapy. It also studies the replication and pathogenicity of SARS-CoV-2.
MembersFaculty
- ProfessorKeizo Tomonaga
- Associate ProfessorAkiko Makino
- Assistant ProfessorTakehiro Kanda
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Novel Coronavirus SARS-CoV- )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Replication and infection mechanisms of bornaviruses: “Bdv c” M.Eickmann / Public domain (cropped)
- Endogenous viruses and virus–host coevolution: “Human karyotype (248 26) Karyotype Human, green filter” Doc. RNDr. Josef Reischig, CSc. / CC BY-SA 3.0 (cropped)
- New viral vectors for gene therapy: “Novel Coronavirus SARS-CoV- )” National Institute of Allergy and Infectious Diseases (NIAID) / CC BY 2.0 (cropped)
- Related lab (ウイルス分子病態分野): “Herpesvirus (negative staining)” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Related lab (微細構造ウイルス学分野): “Influenza A Virus (H3N )” NIAID / CC BY 2.0 (cropped)
- Related lab (がんウイルス分野): “HumanPapillomavirus” NIAID / Public domain (cropped)
- Related lab (細胞制御分野): “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
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