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Biomembrane Systems Lab
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The lab uses bacteria to uncover the mechanisms of membrane proteins that are common to all life.
AboutAbout the lab
The biological membrane mechanisms shared by all life.
The Biomembrane Systems Lab uses bacteria as model organisms to study, with a variety of methods, the fundamental membrane-related processes common to all life.
The lab investigates how proteins are translated, folded, secreted, inserted into membranes, and degraded in the cell, as well as the stress response mechanisms that act when these processes go wrong.
Using approaches such as biochemistry, biophysics, genetics, and structural biology, the lab aims to clarify how proteins at the cell surface of bacteria such as Escherichia coli and Vibrio species function and how their order is maintained.
Key terms
- Biological membrane
- A membrane made of lipids and proteins that surrounds cells and the organelles inside them
- Protein translocation machinery (translocon)
- A molecular apparatus that moves proteins across a membrane or inserts them into it
- Protease
- An enzyme that cleaves proteins
ResearchResearch themes
The lab focuses on two areas: protein translocation machinery, and stress responses and membrane protein degradation.
*Illustrative imageProtein translocation machinery
The lab studies the structure and mechanism of the Sec translocon, which moves proteins across membranes. It also studies how the amount of translocon is regulated through a mechanism that temporarily pauses translation.
*Illustrative imageStress responses and membrane protein degradation
The lab studies the structure and function of proteases that cleave proteins within membranes. It also works to clarify how quality is maintained in the inner and outer membranes of bacteria.
MembersFaculty
- Associate ProfessorHiroyuki Mori
- Assistant ProfessorYohei Hizukuri
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “CCR5 chemokine receptor (molecular surface representation) with an illustration of a cell membrane in the background” NIAID / CC BY 2.0 (cropped)
- Protein translocation machinery: “Ribosome shape” Vossman / CC BY-SA 3.0 (cropped)
- Stress responses and membrane protein degradation: “E. coli Bacteria ( )” NIAID / Public domain (cropped)
- Related lab (メカノセンシング生理学分野): “Piezo1 homotrimer” KormiSK / CC BY-SA 4.0 (cropped)
- Related lab (幹細胞遺伝学分野): “Cas9 5AXW plain” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Related lab (生命データサイエンス分野): “Single Cell RNA Seq (NIH BioArt 767)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (統合生体プロセス分野): “Spermatozoa-human-1000x” No specific author / Public domain (cropped)
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