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Regenerative Immunology Lab
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A lab that studies how T cells are generated and applies this knowledge to cancer treatment by making T cells from iPS cells.
AboutAbout the lab
Understanding and creating T cells.
In hematopoiesis, the differentiation potential of multipotent hematopoietic stem cells becomes progressively restricted, giving rise to progenitor cells of various lineages.
The Regenerative Immunology Lab (Kawamoto Lab) aims to analyze the mechanisms that determine the fate of progenitor cells in this process, with particular emphasis on the pathway leading to T cells. The lab also conducts research on the evolutionary origins of blood cells.
The lab is also developing cancer treatments that use T cells regenerated from iPS cells or ES cells, and is preparing a clinical trial targeting acute myeloid leukemia.
Key terms
- Hematopoietic stem cell
- A stem cell that gives rise to all types of blood cells
- T cell receptor
- A receptor that T cells use to recognize specific markers (antigens). Also called TCR
- Adoptive immunotherapy
- A treatment in which immune cells are expanded or modified outside the body and then returned to the patient
- Phagocyte
- A cell that engulfs and breaks down foreign material and dead cells, such as a macrophage
ResearchResearch themes
The lab is working to clarify the process of blood cell differentiation and to develop cell therapies using regenerated T cells.
*Illustrative imageCell therapy with regenerated T cells
When iPS cells are made from T cells, the T cell receptor genes are inherited. Current adoptive immunotherapy uses the patient's own cells, making it expensive and time-consuming. The lab aims to use iPS cell technology to create T cells that can be used for anyone.
*Illustrative imageEvolution of blood cells
Some primitive invertebrate species have only phagocytes. The lab considers that the diverse types of blood cells evolved with phagocytes at their core, and is investigating their origins.
MembersFaculty
- ProfessorHiroshi Kawamoto
- Associate ProfessorMasaki Miyazaki
- Program-Specific Associate ProfessorShimpei Kawaoka
- Assistant ProfessorSeiji Nagano
- Program-Specific Assistant ProfessorJunji Uehori
- Program-Specific Assistant ProfessorYuka Kobayashi
- Program-Specific Assistant ProfessorRiyo Konishi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Methicillin-resistant Staph bacteria ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Cell therapy with regenerated T cells: “Killer T cells surround a cancer cell” The National Institutes of Health / Public domain (cropped)
- Evolution of blood cells: “Horseshoe crabs mating” Paul VanDerWerf / CC BY 2.0 (cropped)
- Related lab (Developmental Epigenome Lab): “0300 Flourescence Stained new” OpenStax / CC BY 4.0 (cropped)
- Related lab (Integrated Biological Processes Lab): “Spermatozoa-human-1000x” No specific author / Public domain (cropped)
- Related lab (Clinical Foundation Lab): “DNA biochemistry ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Related lab (Life Data Science Lab): “Single Cell RNA Seq (NIH BioArt 767)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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