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Investigative Pathology Lab
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A pathology lab investigating intractable diseases through genome analysis.
AboutAbout the lab
Approaching intractable diseases through genome analysis.
The lab conducts pathology research on intractable diseases that incorporates cutting-edge genome-wide molecular analysis.
In pancreatic cancer, the lab studies how signals involved in cancer cell proliferation stay constantly active, and searches for molecules that can be used for diagnosis and treatment.
For intraductal papillary mucinous neoplasm, the lab examines gene mutations and explores how the tumor arises using genetically engineered mice.
The lab also works on research to advance personalized treatment using organoids derived from surgically resected cancers.
Key terms
- ERK/MAPK
- A mechanism that transmits signals inside the cell that promote processes such as cell proliferation.
- Intraductal papillary mucinous neoplasm
- A mucus-producing tumor that forms inside the ducts of the pancreas. Abbreviated as IPMN.
- Organoid
- A three-dimensional mass of cultured cells that resembles an organ.
ResearchResearch themes
The lab conducts next-generation pathology research on intractable diseases that incorporates molecular analyses covering the whole genome. Recent studies have addressed pancreatic cancer, intraductal papillary mucinous neoplasm, and organoids derived from surgically resected cancers.
*Illustrative imageProliferation Signals and Target Molecules in Pancreatic Cancer
The lab found that in pancreatic cancer, inactivation of DUSP6 combined with activating signals such as mutant KRAS leads to constitutive activation of ERK/MAPK. By comprehensively examining the genes that are induced, it has identified molecules applicable to diagnosis and treatment.
*Illustrative imageDevelopment of Intraductal Papillary Mucinous Neoplasm (IPMN)
The lab described the pathological features of IPMN and showed through genome analysis that GNAS mutations are frequent. It has also shown that IPMN develops in mice in which mutant GNAS and mutant Kras are expressed simultaneously only in the pancreas.
*Illustrative imagePersonalized Treatment with Organoids
The lab established organoids from surgically resected cancers and identified molecular targets by genome analysis. By testing the effects of targeted drugs on the organoids, it showed that personalized treatment can be advanced.
MembersFaculty
- ProfessorTakashi Suzuki
- LecturerKeigo Murakami
- Assistant ProfessorKatsuya Hirose
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNBSEQ-T7” RPSkokie / CC BY-SA 4.0 (cropped)
- Proliferation Signals and Target Molecules in Pancreatic Cancer: “KRAS protein 3GFT” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Development of Intraductal Papillary Mucinous Neoplasm (IPMN): “DNA double helix ( )” Genomics Education Programme / CC BY 2.0 (cropped)
- Personalized Treatment with Organoids: “Petri dish” Linda Bartlett (Photographer) / Public domain (cropped)
- Related lab (Gastroenterological Surgery Lab): “Laparoscopic Hand Instruments 001 JPN” ignis / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Oncology Lab (Institute of Development, Aging and Cancer)): “Olympus-BX61-fluorescence microscope” Masur / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Medical Biochemistry Lab): “Biochemistry laboratory MPI-CBG-panorama” Masur / CC BY-SA 3.0 (cropped)
- Related lab (Genome Preventive Medicine Lab (Tohoku Medical Megabank Organization)): “Laboratory microcentrifuge tubes and pipette tips 02” Gannu03 / CC BY-SA 4.0 (cropped)
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