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Molecular Oncology Lab (Institute of Development, Aging and Cancer)
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The lab investigates how cancer develops by studying how chromosomes are segregated.

AboutAbout the lab
Approaching the mechanisms of cancer through chromosome segregation
The lab studies how chromosomes are segregated into two cells during cell division.
It aims to clarify the relationship between abnormal chromosome segregation and cancer.
The lab values observing chromosome behavior directly under the microscope without preconceptions, then forming hypotheses from those observations and testing them.
It is also developing anticancer drugs that act during mitosis.
Key terms
- chromosomal instability
- Failure of chromosomes to be segregated accurately during cell division. It causes abnormalities in chromosome number and structure
- microtubule
- A tubular fiber inside cells. During cell division, microtubules attach to chromosomes and pull them to opposite sides, segregating them
NewsLab news
A student won the top prize in the presentation contest at the Shudankai research meeting
A paper on the mechanism of chromosomal instability seen in cells of older adults was published in npj Aging
A paper on the effect of CHAMP1 mutations seen in intellectual disability on homologous recombination was accepted by Scientific Reports
A paper on the reduction of the fibrous corona in cancer cells was published in Cancer Science
ResearchResearch themes
In most cancer cells, the number or structure of chromosomes is abnormal, and the cause is that chromosomes are not segregated accurately during cell division (chromosomal instability). By clarifying the mechanisms that control cell division, the lab investigates how chromosomal instability arises in cancer, and also works on developing new cancer therapies. The descriptions on the research page cover work only up to around 2015.
*Illustrative imageElucidating the Mechanisms of Chromosome Segregation
During cell division, replicated chromosomes attach to microtubules and are segregated into two sets. The lab investigates the mechanisms that ensure accurate segregation by examining the functions of newly discovered molecules and motor proteins.
*Illustrative imageDeveloping Anticancer Drugs That Act During Mitosis
The lab studies how anticancer drugs that act during mitosis kill cells. It aims to develop drugs that efficiently induce cell death after mitotic arrest and are less prone to drug resistance.
MembersFaculty
The lab's members are faculty, technical assistants, and doctoral and master's students.As of 2026
- ProfessorKozo Tanaka
- Assistant ProfessorKenji Iemura
- Assistant ProfessorKinue Kuniyasu
- Assistant ProfessorJiayi Ren
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Olympus-BX61-fluorescence microscope” Masur / CC BY-SA 3.0 (cropped)
- Elucidating the Mechanisms of Chromosome Segregation: “Human chromosomes under the microscope 01” Korinna / CC BY 4.0 (cropped)
- Developing Anticancer Drugs That Act During Mitosis: “Chemotherapy vials” Bill Branson (Photographer) / Public domain (cropped)
- Related lab (Tumor Biology Lab (Institute of Development, Aging and Cancer)): “Bacterial cell culture on agar plate ( DNA double helix conformation)” Syed Sajidul Islam / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Medical Biochemistry Lab): “Biochemistry laboratory MPI-CBG-panorama” Masur / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “Rotor for microtubes of an Eppendorf Centrifuge 5430” Karbohut / CC BY-SA 4.0 (cropped)
- Related lab (Medical Biochemistry Lab): “Pipette de laboratoire sur fond blanc au Bénin 03” Adoscam / CC BY-SA 4.0 (cropped)
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