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Gastroenterological Surgery Lab
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A lab that conducts research to improve surgical outcomes in gastroenterological surgery and trains young surgeons.

AboutAbout the lab
Toward surgeons who learn, take on challenges, and change the future.
The Gastroenterological Surgery Lab conducts a variety of research to improve surgical outcomes and trains young surgeons.
Regarding it as the university's role to produce the evidence on which clinical practice guidelines are based, the lab pursues both basic research and clinical research.
It carries out clinical practice and research in each area: esophagus, stomach, lower gastrointestinal tract, hepato-biliary-pancreatic, transplantation and liver, and vascular.
The lab's website presents it together with the Breast and Endocrine Surgery Lab under the name "General Surgery."
Key terms
- Minimally invasive treatment
- Treatment that reduces the burden on the body, for example by using smaller incisions. Thoracoscopic surgery is one example
- Organoids
- A small cluster of cells grown in culture that resembles the structure of an organ
- Liquid biopsy
- A method of obtaining clues about cancer by examining body fluids such as blood
ResearchResearch themes
The lab conducts a variety of research to improve surgical outcomes and trains young surgeons. In each area (esophagus, stomach, lower gastrointestinal tract, hepato-biliary-pancreatic, transplantation and liver, and vascular), it carries out basic and clinical research that addresses clinical problems.
*Illustrative imageMinimally Invasive Treatment and Research for Esophageal Cancer
For esophageal cancer, the lab aims at minimally invasive treatments such as thoracoscopic surgery, robotic surgery, endoscopic submucosal dissection (ESD), and photodynamic therapy. To solve clinical problems, its research covers pathology, radiology, AI, and esophageal motor function widely, from basic to clinical levels.
*Illustrative imageMetabolic Surgery of the Stomach and Gastric Cancer
By performing duodenal-jejunal bypass surgery in rats, the lab has clarified the mechanisms by which surgery improves metabolism. It also conducts research using genetically modified mice to elucidate the pathways through which gastric cancer arises.
*Illustrative imagePersonalized Medicine and the Tumor Microenvironment
The lower gastrointestinal group focuses on research using clinical specimens. Using organoids and primary-cultured cancer-associated fibroblasts, it aims to establish personalized medicine and to elucidate the environment surrounding cancer (the tumor microenvironment).
*Illustrative imageNew Diagnostics and Treatments for Hepato-Biliary-Pancreatic Cancer
The lab is working toward practical use of liquid biopsy using blood and peritoneal lavage fluid. It explores new treatments with patient-derived orthotopic xenograft models, and examines the gut microbiota of pancreatic and biliary tract cancer with the aim of developing treatment strategies that target it.
MembersFaculty
- ProfessorMichiaki Unno
- ProfessorTakashi Kamei
- Associate ProfessorMasamichi Mizuma
- Associate ProfessorShinobu Ohnuma
- Associate ProfessorDijiro Akamatsu
- Assistant ProfessorYoshihiro Sato
- Assistant ProfessorHiroyuki Ogasawara
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laparoscopic Hand Instruments 001 JPN” ignis / CC BY-SA 3.0 (cropped)
- Minimally Invasive Treatment and Research for Esophageal Cancer: “Wishard Hospital infant operating room, c. 1916” Author unknown, digitized by the Indiana State Archives / Public domain (cropped)
- Metabolic Surgery of the Stomach and Gastric Cancer: “Instruments for laparoscopic Hernia Operation” Anpol42 / CC BY-SA 3.0 (cropped)
- Personalized Medicine and the Tumor Microenvironment: “Cells in Cell Culture Dish” Rcchang16 / CC BY-SA 4.0 (cropped)
- New Diagnostics and Treatments for Hepato-Biliary-Pancreatic Cancer: “Clinical Pathology Blood Testing Laboratory in Navi Mumbai, India” Goleisureintl / CC BY 4.0 (cropped)
- Related lab (消化器病態学): “Endoscopy room” Gilo1969 / CC BY 2.0 (cropped)
- Related lab (婦人科学): “Air Force's first robotic surgery training course established at Keesler 161021-F-BD983-031” Kemberly Groue / Public domain (cropped)
- Related lab (泌尿器科学): “New Da Vinci Xi” Alvarogarciamd / CC BY-SA 4.0 (cropped)
- Related lab (病態病理学): “DNBSEQ-T7” RPSkokie / CC BY-SA 4.0 (cropped)
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