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Genome Preventive Medicine Lab (Tohoku Medical Megabank Organization)
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The lab studies how gene activity is regulated and how genomic information can be used in medicine.
AboutAbout the lab
Exploring how genes are regulated and how genomic information can be used in medicine.
The Genome Preventive Medicine field studies the mechanisms that regulate gene expression and builds the foundation for using genomic information in medicine.
Using mast cells, a type of blood cell, as its subject, the lab investigates how gene activity is determined for each cell type.
It also promotes the use of the integrated biobank of the Tohoku Medical Megabank Organization and conducts research on returning disease risk based on genetic information to individuals.
Key terms
- Mast cell
- A type of blood cell. It is the cell type in which this lab studies how genes function.
- GATA2
- A transcription factor. It is the master regulator whose role in gene expression regulation in mast cells this lab focuses on.
- Non-coding region
- A region of the genome in which many variants associated with disease risk have been found. Regions that regulate gene expression are also included here.
ResearchResearch themes
Many variants associated with disease risk have been found in non-coding regions of the genome. This lab investigates how the regions that control gene expression function, and works to build a medical foundation that links genomic information to disease prevention and early treatment.
*Illustrative imageRegulation of gene expression in mast cells
In mast cells, a type of blood cell, the lab focuses on the role of the master regulator GATA2 and studies the mechanisms of cell-specific gene expression regulation. For several important genes, it has identified cis-regulatory regions essential for expression and is advancing their functional analysis.
*Illustrative imageUsing biobanks and returning genetic information
The lab conducts pioneering research on promoting the use of the integrated biobank of the Tohoku Medical Megabank Organization and on returning disease risk based on genetic information to individuals. Its aim is to build the foundation for next-generation medicine that links genomic information to disease prevention and early treatment.
MembersFaculty
- ProfessorKinuko Ohneda
- Associate ProfessorTakahiro Nobukuni
- LecturerYumi Yamaguchi
- Assistant ProfessorHiroko Matsubara
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratory microcentrifuge tubes and pipette tips 02” Gannu03 / CC BY-SA 4.0 (cropped)
- Regulation of gene expression in mast cells: “SEM blood cells” Bruce Wetzel (photographer). Harry Schaefer (photographer) / Public domain (cropped)
- Using biobanks and returning genetic information: “DNA-Helix-Rendering 20220603” PantheraLeo1359531 / CC0 (cropped)
- Related lab (Integrative Genomic Predictive Medicine Lab (Tohoku Medical Megabank Organization)): “Illumina NextSeq 500” Konrad Förstner / CC BY 2.0 (cropped)
- Related lab (Genome Infrastructure Development Lab (Tohoku Medical Megabank Organization)): “DNA Visual Representation of Double-Helix” 作者不詳 / Public domain (cropped)
- Related lab (Genome Function Analysis Lab (Advanced Research Center for Innovations in Next-Generation Medicine)): “20251019 Replica DNA double helix model Berlin 01” Flocci Nivis / CC BY 4.0 (cropped)
- Related lab (Biomarker Discovery Lab (Tohoku Medical Megabank Organization)): “Blood test samples” Fumikas Sagisavas / CC0 (cropped)
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