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Pathological Laboratory Science Lab
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A lab that uses pathology and experiments to unravel breast and prostate cancer.
AboutAbout the lab
Tackling sex hormone-dependent tumors, grounded in pathology.
The lab focuses on breast and prostate cancer and works to elucidate the pathology of sex hormone-dependent tumors.
Both are among the cancers with the highest number of patients in Japan, and their numbers continue to rise. Sex hormones play an important role in their growth and progression.
The lab believes that by studying the actions of sex hormones in detail, it can build new treatment strategies and establish indicators (biomarkers) that predict how well a treatment will work.
Building on pathology, which observes cells and tissues under the microscope, the lab combines experiments using disease models such as cultured cells and verifies its findings with its own hands.
Key terms
- Sex hormone-dependent tumor
- A tumor whose growth and progression are driven by the action of sex hormones. Breast cancer and prostate cancer are examples.
- Extracellular matrix
- Substances such as collagen and hyaluronic acid that fill the space between cells. It also acts as a signal that influences cells.
- NETs (neutrophil extracellular traps)
- Web-like structures made of chromatin and other components that neutrophils release outside the cell when they die.
- Intraoperative rapid diagnosis
- A pathological diagnosis made during surgery within a limited amount of time.
NewsLab news
Paper revealing the link between CLEC2D and chemotherapy resistance in breast cancer accepted to Breast Cancer
Paper on an AI model that assists intraoperative rapid diagnosis of breast cancer accepted to The Tohoku Journal of Experimental Medicine
Paper by a graduate student accepted to The Journal of Steroid Biochemistry and Molecular Biology
Paper by a graduate student accepted to Acta Histochemica et Cytochemica
Paper by a technical assistant accepted to Experimental and Molecular Pathology
ResearchResearch themes
The lab studies how sex hormone-related tumors progress, and why treatments stop working, with a focus on breast and prostate cancer. It combines the pathological approach of examining tissue under the microscope with experiments using disease models such as cultured cells.
*Illustrative imageRegulating the function of stromal cells in tumors
The lab studies how the functions of macrophages and neutrophils inside tumors are regulated. It has found that androgens synthesized by breast cancer cells and HSP70 secreted by breast cancer cells after chemotherapy are important, and it is also focusing on the receptor for NETs released by neutrophils.
*Illustrative imageTreatment resistance and changes in the extracellular matrix
The extracellular matrix that fills the space between cells in a tumor also acts as a signal that influences the cells. The lab studies the relationship between changes in the extracellular matrix during treatment and treatment resistance, focusing on its receptors.
*Illustrative imageChemotherapy resistance and cell-cell interaction in breast cancer
The lab thinks that breast cancer cells that respond well to chemotherapy and cells that respond poorly coexist and influence each other, and that this may lead to resistance. It analyzes the mechanism, focusing on extracellular vesicles that mediate communication between cells.
*Illustrative imageDeveloping AI-based diagnostic tools for breast cancer
To reduce the time and mental burden on pathologists, the lab develops AI tools that support pathological diagnosis, in collaboration with other fields. It is currently working on AI to assist intraoperative rapid diagnosis, which has to be done within limited time.
MembersFaculty
Members of the lab consist of faculty, doctoral and master's students, undergraduate students doing graduation research, technical assistants, and administrative assistants.
- ProfessorTakashi Suzuki
- Associate ProfessorKiyoshi Takagi
- Assistant ProfessorMio Tanaka
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Histologic Slide under MIcroscope” Ed Uthman from Houston, TX, USA / CC BY-SA 2.0 (cropped)
- Regulating the function of stromal cells in tumors: “Histological section of the large intestine (colon)” Otávio Astor Vaz Costa / CC BY 4.0 (cropped)
- Treatment resistance and changes in the extracellular matrix: “Epithelioid cells and macrophages in cell culture” ArkhipovSergey / CC BY-SA 4.0 (cropped)
- Chemotherapy resistance and cell-cell interaction in breast cancer: “Scientist checks cell culture flask on microscope” Peter Saxon / CC BY-SA 4.0 (cropped)
- Developing AI-based diagnostic tools for breast cancer: “Part of whole slide image of a Wilms' tumor of the kidney” Mikael Häggström, M.D. / Public domain (cropped)
- Related lab (Adult Nursing Lab): “Laboratoř titrace” Milda 444 / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Endocrinology Lab): “Polyacrylamide gel electrophoresis of Proteins” Jean-Etienne Minh-Duy Poirrier from Bruxelles, Belgium / CC BY-SA 2.0 (cropped)
- Related lab (Clinical Immunology Lab): “NABL Accredited Pathology Lab and Diagnostic Centre in Kharghar, Navi Mumbai - Full Body Checkup, CBC, Thyroid Blood Test and Home Blood Collection” Goleisureintl / CC BY 4.0 (cropped)
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