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Adult Nursing Lab
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The lab explores how gastric cancer arises by studying the aging of stem cells.
AboutAbout the lab
Exploring how gastric cancer develops through aging and infection.
The Adult Nursing Lab studies the relationship between aging, Helicobacter pylori infection, and gastric cancer, focusing on the underlying molecular mechanisms.
The lab focuses on the processes by which the gastric mucosa atrophies and changes into intestinal metaplasia, a state resembling the intestinal mucosa.
The lab uses mice chronically infected with H. pylori, genetically modified mice, and gastric organoids in its research.
Key terms
- Intestinal metaplasia
- A change in which the gastric mucosa is replaced by cells resembling the intestinal mucosa. It is considered a cause of gastric cancer
- Stem cells
- Cells that differentiate into various cell types and serve as the source for maintaining tissues
- Organoids
- Small, organ-like clusters of cells grown in culture from stem cells and other sources
ResearchResearch themes
Focusing on the immune response to H. pylori and on altered differentiation and aging of stem cells, this lab investigates the molecular biological mechanisms by which gastric cancer arises. Using organoids derived from mouse and human tissue, it analyzes gene function and intracellular signaling.
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MembersFaculty
- ProfessorAkira Imatani
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratoř titrace” Milda 444 / CC BY-SA 4.0 (cropped)
- Gastric carcinogenesis explored through aging and H. pylori: “Gastritis due to Helicobacter pylori, HE 5” Patho / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Endocrinology Lab): “Polyacrylamide gel electrophoresis of Proteins” Jean-Etienne Minh-Duy Poirrier from Bruxelles, Belgium / CC BY-SA 2.0 (cropped)
- Related lab (Pathological Laboratory Science Lab): “Histologic Slide under MIcroscope” Ed Uthman from Houston, TX, USA / CC BY-SA 2.0 (cropped)
- Related lab (Molecular Hematology Lab): “Blood film 01” CDC / Public domain (cropped)
- Related lab (Nursing Technology Development Lab): “An Adhesive Dressing showed in both its packaging and application on a patient” Keithf2008 (Wikimedia Commons) / Kei_Jo (Wikipedia) / Public domain (cropped)
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