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Clinical Immunology Lab
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A lab that explores the mechanisms and treatment of connective tissue diseases through both basic research and clinical practice.
AboutAbout the lab
Creating next-generation medicine through research
The lab studies connective tissue diseases (collagen diseases), chronic inflammatory diseases that affect the whole body, from the perspective of autoimmune mechanisms.
The lab carries out basic research using serum and cells from actual patients, and aims to develop new diagnostic methods and treatments by integrating basic research with clinical practice.
The lab's website is shared with the Department of Rheumatology and Connective Tissue Diseases at Tohoku University Hospital, where the same professor serves as department head.
In April 2025, a fourth-year student from the Department of Health Sciences, Division of Laboratory Science, began graduation research in this lab.
Key terms
- Connective tissue disease (collagen disease)
- A general term for diseases that cause chronic inflammation throughout the body, such as rheumatoid arthritis and systemic lupus erythematosus
- Autoantibody
- An antibody that mistakenly targets components of one's own body. It is found in diseases involving autoimmunity
- Plasmablast
- A large cell found in the blood that has the ability to produce antibodies and to divide
- SARF method
- An expression cloning method unique to this lab, used to identify the binding partner (target antigen) of autoantibodies against vascular endothelial cells
NewsLab news
Paper by Prof. Sato published in Clinical Rheumatology
Paper by Prof. Shirai published in Circulation Journal
Paper by Prof. Shirai published in Tohoku Journal of Experimental Medicine
Paper by a medical student who trained in the lab published in Modern Rheumatology Case Reports
ResearchResearch themes
The lab carries out basic research using patients' serum and cells, focusing on connective tissue diseases such as systemic lupus erythematosus. By linking basic research with clinical practice, it aims to develop new diagnostic methods and treatments.
*Illustrative imageB-cell abnormalities in SLE and targeted therapy
The lab examined plasmablasts, which increase in the blood of patients with systemic lupus erythematosus (SLE), and found that inhibiting the transcription factor FOXM1 can suppress B-cell division. It is now developing molecularly targeted therapy based on characteristics of gene expression.
*Illustrative imageAutoantibodies against vascular endothelial cells
Among the autoantibodies found in the blood of patients with connective tissue diseases, the lab identifies the target antigens of anti-endothelial cell antibodies using its own SARF method. In Takayasu arteritis, it found a new mechanism of lesion formation in which anti-EPCR antibodies block the function that suppresses inflammation.
MembersFaculty
- ProfessorHiroshi Fujii
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “NABL Accredited Pathology Lab and Diagnostic Centre in Kharghar, Navi Mumbai - Full Body Checkup, CBC, Thyroid Blood Test and Home Blood Collection” Goleisureintl / CC BY 4.0 (cropped)
- B-cell abnormalities in SLE and targeted therapy: “Blood cells under the microscope 02” Korinna / CC BY 4.0 (cropped)
- Autoantibodies against vascular endothelial cells: “Bovine Pulmonary Artery Endothelial Cells Fluorescent Image” Erin Rod / CC BY 4.0 (cropped)
- Related lab (Molecular Hematology Lab): “Blood film 01” CDC / Public domain (cropped)
- Related lab (Pathological Laboratory Science Lab): “Histologic Slide under MIcroscope” Ed Uthman from Houston, TX, USA / CC BY-SA 2.0 (cropped)
- Related lab (Nursing Technology Development Lab): “An Adhesive Dressing showed in both its packaging and application on a patient” Keithf2008 (Wikimedia Commons) / Kei_Jo (Wikipedia) / Public domain (cropped)
- Related lab (Medical Physics Lab): “SIEMENS Somatom AR T CT Scanner ( )” Kitmondo Marketplace / CC BY 2.0 (cropped)
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