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Molecular Endocrinology Lab
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A lab that studies hormonal and metabolic diseases at the molecular level, aiming at drug discovery.
AboutAbout the lab
Solving hormonal and metabolic diseases from the molecules up.
The lab conducts research using molecular biological and biochemical approaches, aiming to solve problems in endocrine diseases and lifestyle-related diseases such as diabetes and hypertension.
Its work spans a wide range, from purifying and identifying transcription factor complexes with proteomic approaches to discovering new drugs for diabetic nephropathy and primary aldosteronism through high-throughput screening.
The professor's greeting describes the lab as a rewarding place for students who are interested in clinical medicine but want to pursue basic medical research.
Undergraduates doing graduation research in the Medical Laboratory Science major have also joined as members.
Key terms
- High-throughput screening
- A method that uses robots and similar equipment to select compounds with a desired activity from among a large number of compounds
- Transcription factor
- A protein that acts on DNA to regulate how much a gene is used
- Proteomics
- A method for comprehensively analyzing the proteins in cells, for example by mass spectrometry
- Aldosterone
- A hormone secreted by the adrenal cortex that acts to raise blood pressure
NewsLab news
View More ↗ResearchResearch themes
The lab aims to elucidate the pathophysiology of endocrine and metabolic diseases, metabolic syndrome, and lifestyle-related diseases, and to develop new diagnostic methods, biomarkers, drugs, and treatments. Research uses molecular biological and proteomic approaches and genetically modified mouse models of disease.
*Illustrative imageNew drug discovery for endocrine and metabolic diseases
Using high-throughput screening, the lab searches for compounds that activate or inhibit transcription factors important in endocrine and metabolic diseases. Compounds that are found are structurally optimized in collaboration with the School of Pharmaceutical Sciences, and their efficacy is tested in disease model mice.
*Illustrative imageExploring gene expression through transcription complexes
The lab uses proteomic approaches to purify and identify the complexes of transcriptional coregulators recruited by transcription factors, and studies how gene expression is regulated. It focuses on transcription factors involved in primary aldosteronism, diabetes, and diabetic nephropathy.
*Illustrative imageFactors behind obesity-related hypertension
In obesity, a factor that acts from adipocytes on the adrenal cortex to increase aldosterone secretion has been reported to raise blood pressure. The lab aims to identify this factor and use it to elucidate the pathophysiology of hypertension and to develop biomarkers, diagnosis, and treatment.
MembersFaculty
The lab's members consist of faculty, part-time lecturers, doctoral and master's students, undergraduates doing graduation research, students in basic medical training, and technical assistants.As of 2026
- ProfessorAkira Sugawara
- Associate ProfessorAtsushi Yokoyama
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Polyacrylamide gel electrophoresis of Proteins” Jean-Etienne Minh-Duy Poirrier from Bruxelles, Belgium / CC BY-SA 2.0 (cropped)
- New drug discovery for endocrine and metabolic diseases: “NCATS Robots ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Exploring gene expression through transcription complexes: “Bruker HCTultra mass spectrometer June2007” Mwillett4000 / Public domain (cropped)
- Factors behind obesity-related hypertension: “Blood pressure monitoring” rawpixel.com / CC0 (cropped)
- Related lab (Adult Nursing Lab): “Laboratoř titrace” Milda 444 / CC BY-SA 4.0 (cropped)
- Related lab (Pathological Laboratory Science Lab): “Histologic Slide under MIcroscope” Ed Uthman from Houston, TX, USA / CC BY-SA 2.0 (cropped)
- Related lab (Nursing Technology Development Lab): “An Adhesive Dressing showed in both its packaging and application on a patient” Keithf2008 (Wikimedia Commons) / Kei_Jo (Wikipedia) / Public domain (cropped)
- Related lab (Molecular Hematology Lab): “Blood film 01” CDC / Public domain (cropped)
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