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Medical Physics Lab
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A medical physics lab that investigates cancer and arteriosclerosis using X-ray CT and fluorescence imaging.
AboutAbout the lab
Combining science, engineering, and medicine to visualize how diseases work.
The Medical Physics lab (Gonda Lab) uses nanomedicine to develop imaging technologies that are extremely important for the early diagnosis and treatment of cancer and arteriosclerosis.
Using in vivo imaging of disease model mice, the lab investigates the mechanisms of cancer and peripheral arterial disease and applies the results to developing diagnostic and therapeutic technologies.
The lab is also developing a technology that examines surgically removed human cancer tissue with fluorescence imaging to diagnose, with high accuracy, the likelihood of postoperative recurrence and the efficacy of anticancer drugs.
Members come from diverse backgrounds in science, engineering, and medicine, and conduct research with a strong emphasis on discussion and teamwork.
Key terms
- Nanomedicine
- A research field that combines nanotechnology with medicine and healthcare
- X-ray CT
- A method that creates cross-sectional images of the inside of the body from differences in how X-rays are absorbed as they pass through it. X-ray absorption is proportional to the amount of contrast agent
- Fluorescence imaging
- A method of observing the state of the body or tissue by making fluorescent substances used as markers glow. Fluorescence intensity is proportional to the excitation light output
- Peripheral arterial disease
- A disease in which blood flow is impaired in arteries far from the heart, such as those in the hands and feet
- Vascular remodeling
- Changes in the structure of tubes such as blood vessels as a disease progresses
ResearchResearch themes
The lab works to develop imaging technologies for the early diagnosis and effective treatment of diseases that are leading causes of death, such as cancer and arteriosclerosis. It is developing X-ray CT and fluorescence imaging using nanomedicine, and working to elucidate the mechanisms of disease.
*Illustrative imageHigh-Precision X-ray CT and Fluorescence Imaging
Using nanomedicine, the lab develops highly accurate, highly sensitive X-ray CT and fluorescence imaging technologies. X-ray absorption is proportional to the amount of contrast agent, and fluorescence intensity is proportional to the excitation light output, so both are highly quantitative visualization methods.
*Illustrative imageExploring Disease Mechanisms with Model Mice
Through in vivo imaging of disease model mice, the lab has studied the process of cancer metastasis and the mechanisms of angiogenesis in peripheral arterial disease. This technology is being extended to elucidating the mechanisms of vascular remodeling and to developing foundational technologies for cancer imaging diagnosis and treatment using nanoparticles.
*Illustrative imageApplication to Pathological Diagnosis of Human Cancer Tissue
The lab is applying fluorescence imaging to surgically removed human cancer tissue to develop a technology that diagnoses, with high accuracy, the likelihood of postoperative recurrence in cancer patients and the efficacy of anticancer drugs.
MembersFaculty
The lab's members consist of faculty, part-time lecturers, administrative assistants, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorKohsuke Gonda
- Associate ProfessorNarufumi Kitamura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “SIEMENS Somatom AR T CT Scanner ( )” Kitmondo Marketplace / CC BY 2.0 (cropped)
- High-Precision X-ray CT and Fluorescence Imaging: “CT Abdomen Scan Imaging Navi Mumbai” Goleisureintl / CC BY 4.0 (cropped)
- Exploring Disease Mechanisms with Model Mice: “Microscope stage set up for intravital microscopy” Aleanora / CC BY-SA 4.0 (cropped)
- Application to Pathological Diagnosis of Human Cancer Tissue: “Fluorescence microscopy of the oral cancer cells” Korinna / CC BY 4.0 (cropped)
- Related lab (Medical Image Engineering Lab): “Computed Tomography (CT) Scan Facility in Navi Mumbai” Goleisureintl / CC BY 4.0 (cropped)
- Related lab (Clinical Immunology Lab): “NABL Accredited Pathology Lab and Diagnostic Centre in Kharghar, Navi Mumbai - Full Body Checkup, CBC, Thyroid Blood Test and Home Blood Collection” Goleisureintl / CC BY 4.0 (cropped)
- Related lab (Diagnostic Imaging Lab): “TORNAI-SpectrumOfMedicalImaging” Martin Tornai / CC BY 4.0 (cropped)
- Related lab (Psychiatric and Mental Health Nursing Lab): “Mental health partnership strengthens care during LAMAT 2026 in Saint Kitts and Nevis (9554275)” U.S. Air Force photo by Andrea Jenkins / Public domain (cropped)
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