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Molecular Hematology Lab
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A lab that explores, from the perspective of genes, how blood cells are made and what goes wrong in that process.
AboutAbout the lab
Unraveling the GATA factors that support blood cell differentiation
The Molecular Hematology Lab studies GATA1, which acts in the differentiation of erythrocytes and megakaryocytes, and GATA2, which acts in the differentiation of hematopoietic stem and progenitor cells and immune cells.
In recent years, mutations in the GATA1 and GATA2 genes have been found in hematopoietic disorders such as leukemia, but the relationship between these mutations and disease onset has not been sufficiently verified.
The lab therefore analyzes, at the molecular level, how qualitative and quantitative abnormalities of GATA factors cause disease.
Research centers on analysis in whole animals using genetically modified animals, with the aim of clarifying the molecular basis of anemia, immunodeficiency disorders, and leukemia.
Key terms
- Transcription factor
- A protein that regulates the activity of genes; it is involved in cell fate and differentiation
- Hematopoietic stem and progenitor cells
- Cells that give rise to the various types of blood cells, such as red blood cells and white blood cells
- Genetically modified animals
- Animals in which specific genes have been altered; they are used to study the function of genes in living organisms
ResearchResearch themes
The lab considers that precise control of gene expression, supported by networks of transcription factors, is essential for hematopoiesis, the constant production of blood. It analyzes the molecular mechanisms by which this control breaks down and causes hematopoietic disorders, focusing on abnormalities of GATA factors.
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MembersFaculty
The lab's members consist of faculty, doctoral and master's students, technical staff, and collaborating members from the Tohoku Medical Megabank Organization and the Advanced Research Center for Innovations in Next-Generation Medicine.
- ProfessorRitsuko Shimizu
- Associate ProfessorMikiko Suzuki
- LecturerIkuo Hirano
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Blood film 01” CDC / Public domain (cropped)
- Analyzing GATA Factors with Genetically Modified Animals: “Normal Adult Blood Smear” Keith Chambers / CC BY-SA 3.0 (cropped)
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