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74 labs · 17 student voices
Other departments in School of Life Science and Technology ›Faculties at Institute of Science Tokyo ›
Tetsuya Kadonosono, Associate Professor
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The Kadonosono Lab studies "biopharmaceuticals" made from proteins, peptides, nucleic acids, cells, and other materials. Biopharmaceuticals can be given sophisticated mechanisms that small-molecule drugs cannot achieve, but their effects may not last, or they may cause severe side effects. By advancing design technology, the lab aims to create next-generation biopharmaceuticals with high efficacy and few side effects. It also works on developing diagnostic agents that can detect diseases with ultra-high sensitivity.
Asako Yamayoshi, Professor
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The Yamayoshi Lab studies nucleic acid therapeutics, which use nucleic acids, the substance of genes, to control gene function. It creates new artificial nucleic acids and examines their properties, covering everything from functional evaluation in cells to preclinical studies using laboratory animals. It also works on drug delivery systems using exosomes, small vesicles released by cells, and on artificial nucleic acids whose drug effects can be controlled by light. Through collaborative research with researchers in other fields and industry-academia partnerships, the lab aims for the real-world implementation of nucleic acid therapeutics.
Takeo Saneyoshi, Professor
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The Saneyoshi Lab studies how memories that last a lifetime are maintained. Focusing on synapses, the junctions between neurons in the brain, the lab investigates how molecules preserve memory information. The lab also studies the diseases that arise when these mechanisms break down. Liquid–liquid phase separation, in which proteins cluster together and separate into distinct phases, is one of the key clues.
Yasuka Toda, Associate Professor
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The Toda Lab studies what makes food "delicious" by looking at how taste receptors detect taste. Its methods include functional analysis of taste receptors, gene expression analysis, behavioral experiments, and analysis of food components. Studying a wide range of vertebrates, from fish to mammals, the lab investigates how the sense of taste has changed in response to changes in habitat and diet. The lab also searches foods for yet-unknown components that contribute to deliciousness.
Kengo Sato, Professor
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The Sato Lab studies data-driven bioinformatics using artificial intelligence and machine learning. The lab develops advanced algorithms for analyzing life science and medical data, with the aim of accelerating research in the life sciences. For RNA secondary structure prediction, it has developed methods such as MXfold2, which uses deep learning. The lab also works on drug discovery informatics, which uses computers to find new drug candidates, and on medical AI.
Tomoko Horie, Associate Professor
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Horie Lab studies autophagy, the process by which cells enclose their own contents and degrade them. In particular, the lab focuses on degradation itself, investigating the identity of the degradative enzymes that act in vacuoles and lysosomes. The targets extend beyond proteins to RNA, lipids, sugars, and metabolites. Using yeast, the lab aims to draw a comprehensive atlas of the biomolecules that are degraded, metabolized, and transported.
Ryuji Igarashi, Professor
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Igarashi Lab investigates biological phenomena using nanometer-sized quantum sensors. Using a structure called the NV center in diamond, the lab measures temperature, magnetic fields, and electric fields with high sensitivity. The lab takes on the challenge of quantitatively capturing minute changes inside living cells that have been difficult to measure until now. It also works on building a diagnostic platform that detects early signs of disease from slight abnormalities appearing in blood and other body fluids.
Takuji Yamada, Professor
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Yamada Lab analyzes the wide variety of information obtained from biological experiments by computer, in order to discover biological knowledge that is not yet known. This type of research is called bioinformatics. Because a single experiment can now yield an enormous amount of information, the lab develops methods to analyze it quickly and techniques to visualize multidimensional information in an easy-to-read form. With genome information at the core, the lab connects diverse kinds of information and carries out its research in collaboration with bioscience researchers in Japan and abroad.
Yuriko Osakabe, Professor
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The Osakabe Lab develops genome editing, a new technology for rewriting genes, along with supporting technologies for using it efficiently. The lab also uses genome editing to modify gene function in a variety of organisms. This work builds on knowledge from genes involved in homeostasis and from the mechanisms by which plants respond to their environment. The lab takes on social problems such as treating intractable diseases and food crises caused by environmental change.
Yoshiaki Masaki, Associate Professor
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The Masaki Lab approaches, from the side of organic chemistry, the challenges that stand in the way of putting nucleic acid therapeutics into actual clinical use. Nucleic acid therapeutics have the potential to treat intractable diseases that cannot be cured today. At the same time, many challenges remain to be solved before they can be applied to treatment. The lab confronts the question of why this cannot yet be done, and advances its research by combining nucleic acid chemistry, physical chemistry, biochemistry, and information science.
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