LAB LOGA page on LabLog, a review site (not the lab's official page)
Yamayoshi Lab
Machine-translated · View original
The lab aims to freely control gene function with nucleic acid therapeutics.
AboutAbout the lab
New drug discovery using nucleic acids.
The Yamayoshi Lab studies nucleic acid therapeutics, which use nucleic acids, the substance of genes, to control gene function.
It creates new artificial nucleic acids and examines their properties, covering everything from functional evaluation in cells to preclinical studies using laboratory animals.
It also works on drug delivery systems using exosomes, small vesicles released by cells, and on artificial nucleic acids whose drug effects can be controlled by light.
Through collaborative research with researchers in other fields and industry-academia partnerships, the lab aims for the real-world implementation of nucleic acid therapeutics.
Key terms
- Nucleic acid therapeutics
- A drug made from molecules designed to resemble DNA or RNA. It binds to the sequence of a targeted gene and changes how that gene works.
- Exosome
- A tiny sac that a cell releases to the outside. It carries molecules inside and delivers information to other cells.
- Immunogenicity
- The property of being regarded by the body as a foreign substance and triggering an immune response.
NewsLab news
A student received the Kawahara Award (Outstanding Presentation Award) at the 11th Annual Meeting of the Japanese Society of Nucleic Acids Medicine
Prof. Yamayoshi received the 8th Materials and Devices Joint Research Award
A master's student received the Outstanding Presentation Award of the Human Centered Science and Biomedical Engineering Course
Results of a joint study with another university were published in JACS, and a press release was issued
Results of a joint study with another university were published in ChemMedChem
ResearchResearch themes
Aiming to manipulate gene function using nucleic acids, the substance of genes, the lab conducts broad research ranging from the synthesis and physical property evaluation of new artificial nucleic acids, to functional evaluation in cells, to preclinical studies using laboratory animals. It also actively pursues collaborative research with researchers in other fields and industry-academia partnerships, aiming for the real-world implementation of nucleic acid therapeutics.
*Illustrative imageDrug Delivery Systems Using Exosomes
Exosomes, small vesicles released by cells, carry tiny genetic molecules involved in cancer metastasis and growth. The lab develops antibody-conjugated nucleic acids that are taken up along with exosomes and inhibit the action of these molecules, and aims for the real-world implementation of drug delivery systems based on them.
*Illustrative imageControlling Gene Expression with Light
Nucleic acid therapeutics bind to target genes according to their sequence, so they attract attention as drugs with few side effects. The lab developed artificial nucleic acids whose drug effects can be controlled by light, and succeeded in controlling the function of non-coding RNA in cells and in detecting gene methylation. It is also extending this work to genome editing.
*Illustrative imageArtificial Nucleic Acids Compatible with the Body
Many antibody drugs and nucleic acid drugs are immunogenic, and avoiding this is currently difficult. The lab aims to elucidate at the molecular level why artificial nucleic acids show immunogenicity, and to create new nucleic acid therapeutics that can coexist with the body.
MembersFaculty
The members of the Yamayoshi Lab consist of faculty, doctoral, master's, and undergraduate students, special research students from other universities, and administrative support staff.As of 2026
- ProfessorAsako YamayoshiPublications ↗
- Assistant ProfessorYu MikamePublications ↗
VoicesStudent voices
Ratings and reviews reflect the experiences of individual current or former students, not the lab's official views. Whether a lab has reviews, or how many, says nothing about the lab itself.
Students who take part in an interview may receive a thank-you gift worth ¥1,000, regardless of what they say.
Student ratings (0 students)
--
--
--
--
--
--
Student voices answer questions like these
- What's great about this lab?
- What did you learn after joining?
- What's the vibe, and what is the professor like?
- Who is this lab for?
- Where do graduates go?
Your experience can help younger students choose their lab. Your name won't be shown.
Write a lab reviewAnonymous · Your draft is saved if you stopRelatedLabs similar to Yamayoshi Lab
Nishiyama-Miura LabSchool of Life Science and Technology, Department of Life Science and TechnologyNanomedicines, drug delivery systems (DDS), nanotechnology, …
Seio LabSchool of Life Science and Technology, Department of Life Science and TechnologyOrganic chemistry, genes, nucleic acid therapeutics
Masaki LabSchool of Life Science and Technology, Department of Life Science and TechnologyOrganic chemistry, nucleic acid chemistry, nucleic acid ther…
Osakabe LabSchool of Life Science and Technology, Department of Life Science and TechnologyGenetic engineering, genome editing, molecular biology, plan…The information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNA double helix horizontal” Jerome Walker / Public domain (cropped)
- Drug Delivery Systems Using Exosomes: “Phosphatidylcholine liposomes stained with acridine orange” ArkhipovSergey / CC BY-SA 4.0 (cropped)
- Controlling Gene Expression with Light: “5S ribosomal RNA ribbons” Jane Richardson (Dcrjsr) / CC BY 3.0 (cropped)
- Artificial Nucleic Acids Compatible with the Body: “T Lymphocyte, also known as a T cell (yellow color)” NIAID / CC BY 2.0 (cropped)
- Related lab (西山・三浦研究室): “TEM image of gold nanoparticles and nanorods” Fionán / CC BY-SA 4.0 (cropped)
- Related lab (清尾研究室): “Синтезатор олигонуклеотидов колоночный” Mfomich / CC BY-SA 3.0 (cropped)
- Related lab (正木研究室): “DNA Helix CPK” Ude / Public domain (cropped)
- Related lab (刑部祐里子研究室): “Arabidopsis thaliana kz07” Krzysztof Ziarnek, Kenraiz / CC BY-SA 4.0 (cropped)
About LabLog
LabLog is a lab review app for students only. Student members at each university interview students in labs and publish what they say. Student voices can only be read by students who sign up with a university email address. Operated by bestiee Inc.
Learn more about LabLog ↗Search engines and AI may reference the basic lab info and rating summaries on this page and the description of LabLog. Student voices are for student members only. Automated collection by programs (scraping, or input to or training of AI) is prohibited under Article 8 of the Terms of Service. If you need data for research or analysis, please contact us.