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Kadonosono Lab
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The lab designs next-generation biopharmaceuticals with high efficacy and few side effects.
AboutAbout the lab
Next-generation biopharmaceuticals, created with designer cells.
The Kadonosono Lab studies "biopharmaceuticals" made from proteins, peptides, nucleic acids, cells, and other materials.
Biopharmaceuticals can be given sophisticated mechanisms that small-molecule drugs cannot achieve, but their effects may not last, or they may cause severe side effects.
By advancing design technology, the lab aims to create next-generation biopharmaceuticals with high efficacy and few side effects.
It also works on developing diagnostic agents that can detect diseases with ultra-high sensitivity.
Key terms
- Biopharmaceutical
- A drug made by applying molecules found in living things, such as proteins, peptides, nucleic acids, and cells.
- Designer cell
- A cell whose genes have been recombined so that it can freely handle a targeted molecule.
- Hypoxic region
- A place inside a tumor where blood flow is poor and the oxygen concentration is low.
NewsLab news
A student received the Young Investigator Award at HypoxJP 2025
A master's student received the Outstanding Master's Thesis Presentation Award
A student received a Poster Award at the 7th Annual Meeting of the Japan Society for Quantum Life Science
A master's student received the Outstanding Master's Thesis Presentation Award
A student received an Excellent Poster Award at the 3rd Annual Meeting of the Japanese Society for Antibody Science
ResearchResearch themes
The lab has developed a method that combines structural calculations and big data analysis using supercomputers with designer cells made by genetic recombination, to evaluate the performance of many biopharmaceutical candidate molecules at once and select among them. While advancing this technology, it is now pursuing two lines of research: pioneering design technology for next-generation biopharmaceuticals, and developing probes for ultra-high-sensitivity tumor detection.
*Illustrative imageNext-Generation Biopharmaceutical Design
It has become clear that the strength of binding to a target molecule is related to how long a drug's effect lasts and how severe its side effects are. To optimize binding strength, the lab creates designer cells that can freely manipulate specific molecules and develops the underlying technologies. It also investigates the behavior of dormant cancer cells, a challenge in cancer treatment.
*Illustrative imageNano Quantum Sensors for Tumor Detection
Some tumors contain hypoxic regions with poor blood flow and low oxygen, and the cancer cells there are thought to cause metastasis and recurrence. The lab develops probes that use nanodiamonds and quantum dots to detect this hypoxic environment with ultra-high sensitivity.
MembersFaculty
The members of the Kadonosono Lab consist of faculty, doctoral, master's, and undergraduate students, and international students.As of 2026
- Associate ProfessorTetsuya KadonosonoPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Antibody IgG1 surface” Tokenzero / CC BY-SA 4.0 (cropped)
- Next-Generation Biopharmaceutical Design: “GFP positive myoblasts” RigInScience / CC BY 4.0 (cropped)
- Nano Quantum Sensors for Tumor Detection: “Heterogeneous breast tumor in 3D” Sshah74 / CC BY 4.0 (cropped)
- Related lab (神谷研究室): “Fluorescence rainbow” Maxim Bilovitskiy / CC BY-SA 4.0 (cropped)
- Related lab (五十嵐研究室): “Fluorescent nanodiamonds surrounding living HeLa cells” Autor Skutečný / CC BY-SA 4.0 (cropped)
- Related lab (小倉研究室): “Fluorescence of porphyrine” Sunmosk / CC BY 4.0 (cropped)
- Related lab (越川研究室): “Cancer cells” Dr. Cecil Fox (Photographer) / Public domain (cropped)
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