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74 labs · 17 student voices
Other departments in School of Life Science and Technology ›Faculties at Institute of Science Tokyo ›
Koichiro Uriu, Associate Professor
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The Uriu Lab studies biological phenomena using mathematical models and simulations. One pillar is somite formation: the lab investigates how somites, which give rise to vertebrae and ribs, are formed one at a time at a fixed time interval specific to each species. The other pillar is the circadian clock, the internal clock that keeps a period of about 24 hours even in darkness. Through computation, the lab examines how protein concentrations oscillate inside cells and how cells synchronize their rhythms with one another.
Kuroda Kumi, Professor
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The Kuroda Lab studies the brain mechanisms of affiliative sociality, which underpins parent–child relationships and close relationships in families, workplaces, and communities. Using mice, the lab examines the neural circuits that control social behaviors such as parenting, offspring attachment to parents, altruistic behavior, and aggression. In human studies, the lab takes the "transport response," in which babies become calm when they are carried, as a clue and is developing approaches that help stop crying and put babies to sleep. The lab is also conducting machine learning research that predicts an infant's state from data such as heart rate.
Kayo Nozawa, Associate Professor
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The Nozawa Lab studies the folded structure of genomic DNA and the mechanisms that determine how genes function. Eukaryotic genomic DNA is folded on a foundation of disc-shaped nucleosomes, and changes in this structure regulate mRNA synthesis. Breakdown of this structure causes diseases such as cancer, lifestyle-related diseases, and psychiatric disorders. Using techniques for "peering into the atomic world," such as X-ray crystallography and cryo-electron microscopy, the lab investigates the causes of these diseases from three-dimensional structures.
Shawn Mcglynn, Associate Professor
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The Mcglynn Lab studies how the organization of matter proceeds through the flow of energy. It examines both processes involving living organisms and processes without them, across multiple systems and scales. Its settings include the ways of life of microbes in hot springs, experiments imitating hydrothermal vents, and research tracing the evolutionary history of enzymes. Affiliated with the Earth-Life Science Institute, the lab approaches from chemistry the nature of the energy that triggered the emergence of life.
Susumu Kajiwara, Professor
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The Kajiwara-Orihara Lab studies, at the molecular level, the pathogenic microbes that cause infectious diseases and the mechanisms by which immune diseases arise. The lab investigates the molecular mechanisms involved in the growth, infection, and expression of pathogenicity of pathogenic microbes, as well as the interactions between humans or animals and microbes. In parallel, the lab pursues applied research, such as developing new drugs and preventive methods and developing technologies for producing large amounts of heterologous proteins. The lab also focuses on the circadian clock, with a particular emphasis on research that corrects disruptions of peripheral clocks to restore the balance of immunity.
Tetsuya Kitaguchi, Associate Professor
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The Kitaguchi Lab specializes in bioimaging and analytical chemistry and develops biosensors with original operating principles. By freely combining molecular biology and chemical biology approaches, the lab builds sensors from fluorescent proteins, antibodies, and enzymes. Going beyond visualization and measurement, the lab extends this work to the creation of molecular machines with unique functions. Its goal is to be able to see anything and measure anything.
Naonobu Fujita, Associate Professor
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The Fujita Lab uses Drosophila fruit flies and cultured cells to study how muscle cells are formed and rebuilt. Muscle cells are giant multinucleated cells with highly organized organelles such as T-tubules and the sarcoplasmic reticulum. Their structure and role in muscle contraction are well known, but surprisingly little is understood about the mechanisms that shape them. The lab also works on the physiological functions of autophagy and on the mechanisms that form the slit diaphragm of kidney cells.
Toshinori Fujie, Professor
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The Fujie Lab builds new diagnostic and therapeutic technologies on a foundation of polymer nanofilms. Nanosheets, tens to hundreds of nanometers thick, are exceptionally flexible and adhere directly to living tissue. Key topics are nanobiomaterials, tissue engineering, cell therapy, and wearable and implantable devices. By combining materials, electronic circuits, and living tissue, the lab aims to develop technologies that benefit human health.
Akio Kitao, Professor
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The Kitao Lab uses computer simulation to study how biomolecules carry out their functions. Using large-scale simulation, theory, and structural bioinformatics, it studies proteins, nucleic acids, membranes, and assemblies of biomolecules. Because even complex and diverse life phenomena arise from basic principles such as the laws of physics, they can be understood through physics, chemistry, and mathematics. Drawing on physics, chemistry, computational science, and information science, the lab clarifies life phenomena from the molecular level.
Yasunori Aizawa, Professor
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The Aizawa Lab studies the relationship between the human genome sequence and cell function. Genes (ORFs) account for only 1% of the human genome. The lab re-examines preconceptions about the remaining non-coding regions and explores new causal relationships between genome sequence and cell function (the Genomic Code). The keywords of the research are minimal genomes, genome design, and large-scale genome synthesis.
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