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Osakabe Lab
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The lab rewrites the genes of living organisms through genome editing.
AboutAbout the lab
Developing new genome editing technologies with our own hands
The Osakabe Lab develops genome editing, a new technology for rewriting genes, along with supporting technologies for using it efficiently.
The lab also uses genome editing to modify gene function in a variety of organisms.
This work builds on knowledge from genes involved in homeostasis and from the mechanisms by which plants respond to their environment.
The lab takes on social problems such as treating intractable diseases and food crises caused by environmental change.
Key terms
- Genome editing
- A technology that cuts DNA at a targeted site to rewrite the function of an organism's genes.
- CRISPR-Cas
- A genome editing tool that uses a mechanism found in microbes. RNA serves as a guide, and Cas cuts the DNA.
- Off-target effects
- Unintended changes to DNA at sites other than the target. This remains one of the challenges of genome editing.
NewsLab news
Professor Osakabe selected as a Highly Cited Researcher 2025
Multiple students won the Outstanding Poster Award at the Japan Society for Genome Editing
Professor Osakabe selected as a Highly Cited Researcher 2024
A student won a Poster Award at the master's mid-term progress presentation
A student won a Poster Award at the Annual Meeting of the Molecular Biology Society of Japan
ResearchResearch themes
The lab develops fundamental genome editing technologies for modifying the functions of diverse organisms, and also studies the mechanisms of plant tolerance to environmental stress. In particular, it pursues research on molecular breeding of plants that can adapt to environmental change.
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MembersFaculty
The Osakabe Lab consists of faculty, doctoral, master's, and undergraduate students, researchers, and technical staff.As of 2026
- ProfessorYuriko OsakabePublications ↗
- Assistant ProfessorSatoshi KidokoroPublications ↗
- Assistant ProfessorTadaomi FurutaPublications ↗
- Project Assistant ProfessorKohei KawaguchiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Arabidopsis thaliana kz07” Krzysztof Ziarnek, Kenraiz / CC BY-SA 4.0 (cropped)
- Development of genome editing technology: “Streptococcus pyogenes Cas9-DNA-RNA complex PDB 4OO8” Deposition authors: Nishimasu, H., Ishitani, R., Nureki, O.; Visualization author: Synpath / CC0 (cropped)
- Related lab (藤研究室): “Xenopus laevis nucleosome, Histone H3.3C (2) 1AOI” Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ / CC0 (cropped)
- Related lab (増田研究室): “Cyanobacteria guerrero negro” NASA / Public domain (cropped)
- Related lab (山口研究室): “DAPI-stained nuclei of HeLa cells” DrBib / CC BY 4.0 (cropped)
- Related lab (清尾研究室): “Синтезатор олигонуклеотидов колоночный” Mfomich / CC BY-SA 3.0 (cropped)
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