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Saneyoshi Lab
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The lab uncovers, at the molecular level, how memories that last a lifetime are maintained.
AboutAbout the lab
Uncovering the molecular mechanisms that maintain memory.
The Saneyoshi Lab studies how memories that last a lifetime are maintained.
Focusing on synapses, the junctions between neurons in the brain, the lab investigates how molecules preserve memory information.
The lab also studies the diseases that arise when these mechanisms break down.
Liquid–liquid phase separation, in which proteins cluster together and separate into distinct phases, is one of the key clues.
Key terms
- Synapse
- The junction where neurons exchange signals with one another.
- Synaptic plasticity
- The property by which the strength of synaptic transmission changes depending on how the synapse is used. It forms the basis of learning and memory.
- Liquid–liquid phase separation
- A phenomenon in which proteins and other molecules in a cell gather and form separate liquid droplets, much as oil and water separate.
ResearchResearch themes
How are memories that last a lifetime maintained? The Saneyoshi Lab studies the molecular mechanisms that maintain memory information, and the diseases caused when those mechanisms break down.
*Illustrative imageMolecular mechanisms that maintain memory
The lab investigates which molecular processes preserve memory information at synapses, the junctions between neurons. Changes in the shape of dendritic spines and liquid–liquid phase separation, in which proteins cluster together and separate into distinct phases, serve as key clues.
*Illustrative imageDiseases caused by the breakdown of these mechanisms
The lab investigates which diseases result when the molecular mechanisms that support memory are disrupted. It studies the link between abnormal assembly of synaptic proteins and neurodevelopmental disorders.
MembersFaculty
- ProfessorTakeo SaneyoshiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Нейрон коры с множеством дендритных шипиков” Sergb95 / CC BY-SA 4.0 (cropped)
- Molecular mechanisms that maintain memory: “CA2 amigo2 eGFP mouse” Dudek, Serena; Curuana, Douglas; Carstens, Kelly / CC BY-SA 3.0 (cropped)
- Diseases caused by the breakdown of these mechanisms: “Colorful Neurogenesis” Anna Engler / CC BY-SA 4.0 (cropped)
- Related lab (鈴木崇之研究室): “Visualization of the Drosophila blood brain barrier ( )” Gerit Linneweber / CC BY 2.0 (cropped)
- Related lab (中村信大研究室): “Multicolor fluorescence image of a living PC-12 cell” 8x57is / CC BY-SA 4.0 (cropped)
- Related lab (刑部祐里子研究室): “Arabidopsis thaliana kz07” Krzysztof Ziarnek, Kenraiz / CC BY-SA 4.0 (cropped)
- Related lab (戸田研究室): “Volcano hummingbird (Selasphorus flammula) female in flight 2” Charles J. Sharp / CC BY-SA 4.0 (cropped)
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