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42 labs · 3 student voices
Faculties at Tokyo University of Science ›
Kanami Mori-Mori-Yasumoto, Associate Professor
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The Mori-Yasumoto Lab conducts research in natural products chemistry, searching natural resources such as plants for compounds that could serve as the basis of treatments for tropical infectious diseases. Plants have been deeply involved in human clothing, food, and shelter since ancient times, and have also served as a source of medicines. Unknown chemical substances produced by plants may include some that can be used as drugs, and the lab particularly searches for compounds effective against hard-to-treat tropical infectious diseases. The lab also works to elucidate the active compounds and functions of medicinal plants that have traditionally been used in medicine in tropical regions and elsewhere.
Gaku Ichihara, Professor
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The Ichihara Lab studies the mechanisms by which environmental chemicals and nanoparticles cause nervous system disorders and cancer. It is becoming clear that environmental factors activate immune cells involved in inflammation, such as macrophages and microglia, and that this leads to disease. Using neural stem cells, genetically modified animals, and techniques for analyzing gene expression and the proteome, the lab investigates cell-cell interactions and the molecular basis of pre-disease states (mibyo). The lab aims to establish biomarkers that predict disease and to use them to help prevent illness.
Satoru Miyazaki, Professor
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The Miyazaki Lab studies how to extract new knowledge that serves as a foundation for drug discovery from large-scale biological data, including gene data on genomes. The lab aims to extract this knowledge using databases and virtual experiments based on computer simulations. The lab is working to create drug discovery informatics, a new field of computer science that works in concert with experimental biology and experimental chemistry. Its fields of specialization are bioinformatics, information science, and databases, and its listed research areas are drug discovery informatics, gene structure, and molecular evolution.
Shuji Shimada, Professor
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The Shimada Lab conducts research aimed at providing clinical practice with information for the proper use of medicines. Using meta-analysis, a statistical method that collects and analyzes data from past clinical studies, the lab evaluates whether drug usage and treatments are truly effective. In the fifth year, students look for research seeds during their training at hospitals and pharmacies. In the sixth year, they build on these seeds to conduct experimental research, such as proposing new hospital-prepared formulations and examining dosing methods.
Satoru Goto, Professor
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The Goto Lab studies how the components of drugs behave in solution from the viewpoint of physical chemistry. The lab explains that when structural formulas are viewed as geometric figures, drug molecules can be seen moving around like gymnasts performing on apparatus. The lab thinks this movement may be linked to biological activity and therapeutic effects, and investigates it using computers, NMR, and X-ray crystallography. The lab is listed among the labs of both the Department of Pharmacy and the Department of Pharmaceutical Life Sciences in the Faculty of Pharmaceutical Sciences.
Akiyoshi Saitoh, Professor
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The Saitoh Lab studies why mental and brain disorders such as depression and anxiety disorders arise, from the standpoint of pharmacology, which examines how drugs affect the functions of the body. Through experiments using animal models of disease and tissue, the lab identifies the neural circuits and biological substances involved. Based on these findings, the lab aims to develop new therapeutic drugs and preventive methods. The lab also conducts joint research with outside research institutions, including the International Institute for Integrative Sleep Medicine at the University of Tsukuba and the National Center of Neurology and Psychiatry.
Kyohei Higashi, Associate Professor
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The Higashi Lab studies the structure and function of glycans attached to the proteins that make up our bodies. About 70% of proteins carry glycans, but their structural diversity makes analysis difficult, and their functions remain largely unclarified. For glycans extracted from biological samples, the lab examines structure and functionality using reliable, highly sensitive analytical methods. The lab also takes on developing new trace analysis methods, aiming to elucidate pathological mechanisms from the changes in glycan structure that accompany disease.
Tatsuya Higashi, Professor
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The Higashi Lab aims to extract information on extremely small amounts of biomolecules from samples that place little burden on subjects, such as saliva, and to apply it to disease diagnosis and treatment. The amounts involved are at the picogram (one trillionth of a gram) level. The lab takes on this challenge based on high-performance liquid chromatography–mass spectrometry. The field of specialization is analytical science, and the research field is clinical analytical science.
Shingo Sakurai, Professor
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The Sakurai Lab works on quality assurance of pharmaceuticals and regenerative medicine products from two sides: research on standards and human resource development. It is a social collaboration chair established at Tokyo University of Science in July 2020, aiming to support stronger collaboration among industry, government, and academia through education and research on the quality and GMP of pharmaceuticals and related products. The lab's mission is to promote regulatory harmonization through research on global standards and guidelines, and to apply the latest knowledge gained to human resource development. On the lab's website, it is introduced under the name “Pharmaceutical Quality and GMP Chair.”
Yohei Kawano, Lecturer
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The Pharmacotherapeutics Lab studies how drugs should be used by examining how people respond when they are given a drug. The lab confirms these responses using pharmacoepidemiology methods and tests the reasons behind them in basic research using cultured cells and laboratory animals. The lab designs studies to answer pharmacists' clinical questions and carries them out jointly with clinical sites. Lecturer Yohei Kawano's research topics include data-driven drug repositioning, which re-evaluates existing drugs to find new indications.
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