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Goto Lab
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A lab that uses physical chemistry to explore how drug molecules behave in solution.
AboutAbout the lab
Reading the motion of drug molecules through physical chemistry.
The Goto Lab studies how the components of drugs behave in solution from the viewpoint of physical chemistry.
The lab explains that when structural formulas are viewed as geometric figures, drug molecules can be seen moving around like gymnasts performing on apparatus.
The lab thinks this movement may be linked to biological activity and therapeutic effects, and investigates it using computers, NMR, and X-ray crystallography.
The lab is listed among the labs of both the Department of Pharmacy and the Department of Pharmaceutical Life Sciences in the Faculty of Pharmaceutical Sciences.
Key terms
- Association colloid
- A particle-like cluster formed when molecules gather together in solution
- NSAIDs
- Short for non-steroidal anti-inflammatory drugs, a group of drugs that reduce inflammation and pain
- Singular value decomposition
- A mathematical method that examines a table of data by separating it into basic components and their strengths
- Morphological analysis
- A method that examines text by dividing it into the smallest units, such as words
ResearchResearch themes
The lab regards a drug as the solution obtained by multidimensionally optimizing molecular structure with respect to pharmacological activity, pharmacokinetics, and toxicity. Noting that methods for analyzing pharmacokinetics and toxicity are still developing, the lab aims to clarify unified principles governing solution structure and the formation of molecular complexes.
Analyzing Interactions Focused on Drug Charge
The lab analyzes interactions between the acidic groups of non-steroidal anti-inflammatory drugs (NSAIDs) and the basic groups or nitrogen-containing heterocyclic structures of local anesthetics, aiming to extract the parameters involved.
A Database of Drug Package Inserts
In its research analyzing drug package inserts by morphological analysis, the lab aims to build a database that serves as a bridge for sharing drug information between clinical practice and basic research.
Reading States in Solution from Spectra
The lab proposes that solutions of drug components may behave as if molecules and association colloids are in equilibrium. It says that by analyzing spectra such as UV-vis and FTIR with singular value decomposition, it can visualize the pathways along which these states interconvert.
MembersFaculty
- ProfessorSatoru Goto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
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