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Higashi Lab
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A lab that explores the mechanisms of disease through the structure and function of glycans.
AboutAbout the lab
Approaching the mechanisms of disease through glycan structure.
The Higashi Lab studies the structure and function of glycans attached to the proteins that make up our bodies.
About 70% of proteins carry glycans, but their structural diversity makes analysis difficult, and their functions remain largely unclarified.
For glycans extracted from biological samples, the lab examines structure and functionality using reliable, highly sensitive analytical methods.
The lab also takes on developing new trace analysis methods, aiming to elucidate pathological mechanisms from the changes in glycan structure that accompany disease.
Key terms
- Glycan
- A molecule made of sugars linked in a chain. It is attached to proteins, and its structural diversity makes it difficult to analyze
- Chondroitin sulfate
- A substance with a glycan structure. This lab studies its extraction from underutilized resources and its accumulation in cerebral infarction
- Cerebral infarction model mouse
- A mouse in which cerebral infarction has been reproduced. It is used to examine changes in the acute and chronic phases
ResearchResearch themes
Glycans attached to proteins are structurally diverse and difficult to analyze, and their functions are largely unknown. Using glycan analysis methods and taking on the development of new trace analysis methods, the lab aims to elucidate glycan structure and functionality and to understand the mechanisms of disease.
*Illustrative imageHighly Sensitive Glycan Analysis and Elucidation of Disease Pathology
The lab elucidates the structure of glycans extracted from biological samples and examines their functionality. It also takes on developing new trace analysis methods and explores pathological mechanisms from the changes in glycan structure that accompany disease.
*Illustrative imageChondroitin Sulfate Function and Cerebral Infarction
The lab extracts functional proteoglycans and chondroitin sulfate contained in underutilized resources and examines their functionality from their glycan structure. In cerebral infarction model mice, it examines the degradation of the glycocalyx lining the inside of blood vessels in the acute phase and the accumulation of chondroitin sulfate in the chronic phase.
MembersFaculty
- Associate ProfessorKyohei Higashi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Sugar 1” Gaurav Dhwaj Khadka / CC BY-SA 4.0 (cropped)
- Highly Sensitive Glycan Analysis and Elucidation of Disease Pathology: “Sugar 2xmacro” Lauri Andler (Phantom) / CC BY-SA 3.0 (cropped)
- Chondroitin Sulfate Function and Cerebral Infarction: “Chondroitin Sulfate Structure NTP” The original uploader was Prithason at English Wikipedia. (Original text: National Toxicology Program) / Public domain (cropped)
- Related lab (東(達)研究室): “Biological Mass Spectrometry ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Related lab (西川研究室): “Exosome with hsp70” Guillaume Pelletier / CC BY-SA 4.0 (cropped)
- Related lab (斎藤研究室): “Mouse brain cells” Cody Siciliano / CC BY-SA 4.0 (cropped)
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