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Higashi Lab
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A clinical analytical science lab that works toward disease diagnosis from trace components in samples such as saliva.
AboutAbout the lab
Measuring trace molecules from samples that place little burden on subjects.
The Higashi Lab aims to extract information on extremely small amounts of biomolecules from samples that place little burden on subjects, such as saliva, and to apply it to disease diagnosis and treatment.
The amounts involved are at the picogram (one trillionth of a gram) level.
The lab takes on this challenge based on high-performance liquid chromatography–mass spectrometry.
The field of specialization is analytical science, and the research field is clinical analytical science.
Key terms
- High-performance liquid chromatography–mass spectrometry
- An analytical method that separates the components in a sample and then detects them using their mass.
- Derivatization reagent
- A reagent that acts on the compound to be measured to increase its response in mass spectrometry.
- Dried blood spot (DBS)
- A test sample made by soaking blood into filter paper and drying it.
ResearchResearch themes
Accurately capturing changes in the levels of biomarkers in the body is essential for early detection and diagnosis of disease and for confirming treatment effects. The lab develops testing methods that place little burden on subjects, using samples such as saliva and nails, as well as reagents and techniques for measuring trace molecules with high sensitivity.
*Illustrative imageNoninvasive tests using saliva
The lab develops clinical testing methods that use saliva as the test sample and place little burden on subjects. Besides saliva, it also works on hormone assays that use nails or dried blood spots (DBS) as samples.
*Illustrative imageHighly sensitive, high-resolution derivatization methods
Molecules in samples are present in extremely small amounts, and even LC/ESI-MS/MS often lacks sufficient sensitivity. The lab therefore develops derivatization reagents and methods that greatly enhance response, and is also working on multifunctional reagents that can distinguish isomers.
*Illustrative imageAnalytical science research on steroids
The lab continues clinical analytical science research on bioactive steroids. It studies neuroactive steroids from an analytical science perspective as stress-protective factors within the body.
MembersFaculty
- ProfessorTatsuya Higashi
VoicesStudent voices
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Write a lab reviewAnonymous · Your draft is saved if you stopRelatedLabs similar to Higashi Lab
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Biological Mass Spectrometry ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Noninvasive tests using saliva: “UC Davis Engineers Invent Viscous Fluid Shaker for COVID-19 Saliva Samples” UC Davis College of Engineering / CC BY 2.0 (cropped)
- Highly sensitive, high-resolution derivatization methods: “HPLC(high performance liquid chromatography)” Manojkumar Subramani / CC BY-SA 4.0 (cropped)
- Analytical science research on steroids: “LC MS pic” US gov / Public domain (cropped)
- Related lab (東(恭)研究室): “Sugar 1” Gaurav Dhwaj Khadka / CC BY-SA 4.0 (cropped)
- Related lab (西川研究室): “Exosome with hsp70” Guillaume Pelletier / CC BY-SA 4.0 (cropped)
- Related lab (斎藤研究室): “Mouse brain cells” Cody Siciliano / CC BY-SA 4.0 (cropped)
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