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Medicinal Synthetic Chemistry Lab (Chemical Pharmaceutical Sciences)
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A synthetic organic chemistry lab that works on everything from developing new reactions to synthesizing biologically active natural products.
AboutAbout the lab
Developing new reactions, toward compounds that surpass nature.
The lab develops new organic reactions and reagents and, as applications of them, studies the synthesis of biologically active natural products and their derivatives.
The lab predicts properties and reactivity from molecular structure, pursues a single reaction in depth, and discovers new reactions.
The reactions it discovers are applied to drug discovery research, with the aim of creating new compounds that surpass those found in nature.
The lab also aims to train experts in synthetic organic chemistry through its research.
Key terms
- Asymmetric synthesis
- A synthetic method for selectively making a particular three-dimensional form of a molecule. It is considered essential for synthesizing biologically active compounds, including pharmaceuticals.
- Biologically active natural products
- Substances made by living organisms that act on living systems. This lab studies their synthesis.
- Protecting group
- A structure that temporarily covers a part of a molecule that should not react. Acetals and ketals are protecting groups for the carbonyl group.
NewsLab news
Paper published in Organic Chemistry Frontiers
Paper published in Green Chemistry
Paper by a 6th-year undergraduate student published in Organic Letters
Paper selected for the Front Cover of Organic & Biomolecular Chemistry
ResearchResearch themes
The lab develops a variety of fundamental reactions and, as applications of them, synthesizes biologically active natural products and their derivatives. Returning to the fundamentals of organic chemistry, it pursues reactions in depth, aiming to apply them to drug discovery research.
*Illustrative imageDevelopment of New Organic Reactions and Reagents
The lab focuses on developing reactions that make use of the properties of heteroatoms such as oxygen, nitrogen, sulfur, and phosphorus. Using a pyridinium salt intermediate, it developed a reaction that, among protecting groups for the carbonyl group, removes only the acetal while leaving the ketal in place.
*Illustrative imageDevelopment of New Asymmetric Synthesis Reactions
The lab develops asymmetric synthesis reactions based on its own approach centered on symmetry. Applying a method that creates multiple stereocenters in a single step, it synthesized natural products with anticancer and anti-HIV activity in fewer steps than before.
MembersFaculty
The members of the Medicinal Synthetic Chemistry Lab consist of faculty members, visiting faculty, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorMitsuhiro Arisawa
- Associate ProfessorAtsushi Nakayama
- Assistant ProfessorMizuhito Yanagihara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ballon bi-col 250mL” MrXandorf / CC BY-SA 4.0 (cropped)
- Development of New Organic Reactions and Reagents: “Three Schlenk flasks” Ichwarsnur / CC BY-SA 4.0 (cropped)
- Development of New Asymmetric Synthesis Reactions: “Visible Light Photochemistry Setup” Joanna Yang / CC BY-SA 4.0 (cropped)
- Related lab (Regulatory Science of Medicinal Products and Medical Devices Lab (Medical and Hygienic Pharmaceutical Sciences)): “Drug delivery ru” Ширинский Владимир Павлович, Борисенко Григорий Геннадиевич, Бородин Павел Андреевич / CC BY-SA 3.0 (cropped)
- Related lab (Bioorganic Chemistry Lab (Chemical Pharmaceutical Sciences)): “DNA Ligase DNA Replication” Christinelmiller / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Biology Lab (Life Pharmaceutical Sciences Area)): “Gene therapy” 作者不詳 / Public domain (cropped)
- Related lab (Biological Structure and Function Analysis Lab): “MiTeGen Crystal Mounts” Henrysz / CC BY 4.0 (cropped)
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