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Regenerative Adaptation Lab (Life Pharmaceutical Sciences)
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A lab that works toward developing treatments for muscle diseases, starting from skeletal muscle stem cells.
AboutAbout the lab
Clarifying skeletal muscle regeneration and hypertrophy at the molecular level.
The Regenerative Adaptation Lab studies the regenerative and hypertrophic capacities of skeletal muscle at the molecular level, aiming for discoveries that form the foundation for developing treatments for muscle diseases.
The lab investigates how muscle satellite cells, the stem cells of skeletal muscle, are kept in a quiescent state, and how muscle hypertrophy and muscle regeneration occur.
In addition to muscle diseases such as muscular dystrophy, the lab is interested in sarcopenia and cancer cachexia, where muscle atrophy is a problem.
Key terms
- Muscle satellite cells
- The stem cells of skeletal muscle. The lab investigates how they are kept in a quiescent state.
- Muscular dystrophy
- A type of muscle disease. The lab conducts fundamental research toward developing treatments for muscle diseases.
- Sarcopenia
- A condition in which muscle atrophy is a problem. The lab is interested in it as a target of its research on treatments for muscle diseases.
NewsLab news
A student received the Student Award (Excellence Prize) at the 12th Annual Meeting of the Japan Society of Myology
An invited review summarizing research on regenerative therapy for muscular dystrophy published in Cell Regeneration
Joint research with Kyoto Prefectural University published online in PNAS
A student received the Kusumoto Prize and the Osaka University Outstanding Research Award for Female Graduate Students
A student received an Excellence Award at the interim presentation of the long-term project practicum
ResearchResearch themes
The lab investigates the regenerative and hypertrophic capacities of skeletal muscle at the molecular level, with a focus on stem cells. It aims to use its findings as a foundation for developing treatments for muscle diseases, including hereditary muscle diseases.
*Illustrative imageHow muscle stem cells stay quiescent
The lab investigates how muscle satellite cells, the stem cells of skeletal muscle, are kept in a quiescent state. It continues research focused on Hey1/HeyL, effectors of Notch signaling, and on the Calcitonin Receptor.
*Illustrative imageHow skeletal muscle grows larger
Why does skeletal muscle grow with resistance training? How are muscle hypertrophy and muscle damage related? Are satellite cells required? The lab takes on these classic questions from its own perspective, as research themes that can be tackled precisely because of the present moment.
*Illustrative imageHow skeletal muscle regenerates
Muscle regeneration is completed when multiple types of cells work in an orderly way in time and space. The lab explores the mechanisms of regeneration, focusing on the interactions among muscle satellite cells, blood-lineage cells, stromal cells, and the basement membrane.
*Illustrative imageDeveloping treatments for muscle diseases
Based on its own research results, the lab conducts fundamental research toward developing treatments for hereditary muscle diseases. It is currently interested not only in hereditary muscle diseases but also in sarcopenia and cancer cachexia, where muscle atrophy is a problem.
MembersFaculty
The lab's members are faculty, researchers, doctoral, master's, and undergraduate students, and a secretary.As of 2026
- ProfessorSoichiro Fukada
- LecturerKentaro Jingushi
- Assistant ProfessorHiroaki Hase
- Assistant ProfessorAtsushi Kubo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Skeletal muscle 400x” Alexander G. Cheroske / CC BY-SA 4.0 (cropped)
- How muscle stem cells stay quiescent: “Multinuclear muscle fiber cells and some associated mononuclear cells” MethylC5 / CC BY-SA 4.0 (cropped)
- How skeletal muscle grows larger: “Skeletal Muscle Tissue” Community College Bioscience / CC0 (cropped)
- How skeletal muscle regenerates: “Muscle Tissue Skeletal Muscle Fibers ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Developing treatments for muscle diseases: “Central core disease NADH stain” Jensflorian / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Biology Lab (Life Pharmaceutical Sciences Area)): “Gene therapy” 作者不詳 / Public domain (cropped)
- Related lab (Cardiovascular Drug Discovery Lab (Medical and Hygienic Pharmaceutical Sciences)): “Blood vessels-MIP” Antonino Paolo Di Giovanna / CC BY-SA 4.0 (cropped)
- Related lab (Clinical Drug Efficacy Analysis Lab (Medical and Public Health Pharmaceutical Sciences)): “CT Coronary Artery Imaging” Goleisureintl / CC BY 4.0 (cropped)
- Related lab (Biological Response Regulation Lab (Life Pharmaceutical Sciences)): “Laboratory desk” Goldmund100 / CC BY-SA 3.0 (cropped)
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