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Molecular Biology Lab (Life Pharmaceutical Sciences Area)
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A lab that studies iPS cells and gene therapy, starting from gene delivery technology.
AboutAbout the lab
Studying stem cells and drug discovery, centered on gene transfer technology
The Molecular Biology Lab (Life Pharmaceutical Sciences Area) develops technologies for introducing genes into cells to control their function, and conducts molecular biology research using those technologies.
The lab also creates hepatocytes and intestinal epithelial cells from stem cells such as human iPS cells, and uses them in drug discovery research.
The lab's website also introduces it under the name "Mizuguchi Lab."
Key terms
- iPS cells
- Stem cells that can differentiate into cells of various tissues. They are expected to be applied to systems for testing drug toxicity and to regenerative medicine.
- Adenovirus vector
- An adenovirus used as a tool to carry genes into cells. It can express a target gene transiently and efficiently.
- Differentiation
- The process by which stem cells turn into cells of a specific tissue, such as liver cells.
ResearchResearch themes
Gene transfer and expression control technologies are essential foundational technologies for advancing life science research. The lab develops these technologies, conducts molecular biology research using them, and carries out drug discovery research using hepatocytes and intestinal epithelial cells made from human iPS cells and other sources. The list of research topics also includes functional analysis of non-coding RNAs and development of genome editing technology.
*Illustrative imageGenerating hepatocytes from iPS cells
The lab analyzes the differentiation of human iPS cells into hepatocytes and small intestinal epithelial cells at the molecular level. For hepatocytes, it uses adenovirus vectors to introduce genes important for liver development at appropriate times, in an attempt to promote differentiation.
*Illustrative imageDeveloping vectors that deliver genes
The lab genetically engineers the surface proteins of adenoviruses to develop vectors that can select their target cells, among other designs. It is also working on applications to gene therapy, regenerative medicine, and vaccines, and on clarifying how innate immunity is activated.
MembersFaculty
The members of the Molecular Biology Lab consist of faculty, project researchers, administrative assistants, doctoral, master's, and undergraduate students, visiting faculty, and visiting researchers.As of 2026
- ProfessorHiroyuki Mizuguchi
- Associate ProfessorKahori Shimizu
- Assistant ProfessorYukiko Ueyama
- Project Assistant ProfessorTatsuya Inui
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Gene therapy” 作者不詳 / Public domain (cropped)
- Generating hepatocytes from iPS cells: “Hepatocyte (NIH BioArt 202)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Developing vectors that deliver genes: “Adenovirus D26 wiki” Victor Padilla-Sanchez, PhD / CC BY 4.0 (cropped)
- Related lab (Bioorganic Chemistry Lab (Chemical Pharmaceutical Sciences)): “DNA Ligase DNA Replication” Christinelmiller / CC BY-SA 4.0 (cropped)
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