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Bioorganic Chemistry Lab (Chemical Pharmaceutical Sciences)
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A lab that combines chemistry and biology to turn nucleic acids into drugs.
AboutAbout the lab
Research to make nucleic acids useful as drugs.
The lab conducts research grounded in nucleic acid chemistry, with the aim of making nucleic acids useful as drugs.
Within the lab, there is a chemistry-based group and a biology-based group.
The chemistry group works on chemically modifying nucleic acids using organic chemistry to enhance their usefulness as pharmaceuticals.
The biology group aims to treat diseases by controlling the function of disease-related RNA.
Key terms
- Nucleic acid therapeutics
- Pharmaceuticals whose active ingredient is a nucleic acid such as DNA or RNA.
- Sugar-bridged artificial nucleic acids
- Artificial nucleic acids made by adding a bridge to the sugar moiety of a nucleic acid. They have high affinity for complementary strand nucleic acids.
- Antisense method
- A method that uses nucleic acids to control the function of disease-related RNA, aiming to treat disease.
NewsLab news
A doctoral student received the Kawahara Award at the 11th Annual Meeting of the Japanese Society of Nucleic Acids Medicine
Lecturer Takashi Osawa received the FY2026 Encouragement Award from the Japanese Society of Nucleic Acids Medicine
A doctoral student received an Excellent Presentation Award at the 149th Kinki Regional Meeting of the Japanese Pharmacological Society
A doctoral student received the Best Presentation Award (Young Researcher Category, Top Prize) at the 74th Annual Conference on Mass Spectrometry
Doctoral and undergraduate students received Student Excellent Presentation Awards at the 146th Annual Meeting of the Pharmaceutical Society of Japan
ResearchResearch themes
The lab conducts research grounded in nucleic acid chemistry, aiming to make nucleic acids useful as drugs. Within the lab, there is a chemistry-based group and a biology-based group.
*Illustrative imageChemical Modification of Nucleic Acids and Artificial Nucleic Acids
This research modifies the sugar, base, and phosphate moieties of nucleic acids using organic chemistry to enhance their usefulness as pharmaceuticals. The lab has shown that sugar-bridged artificial nucleic acids, which carry a bridge on the sugar moiety, have high affinity for complementary strand nucleic acids and are highly useful as nucleic acid therapeutics.
*Illustrative imageTherapies That Control RNA Function
Focusing on the diverse roles that RNA, transcribed from DNA, plays in the body, the lab aims to treat diseases by controlling the function of disease-related RNA, mainly through the antisense method. It uses the sugar-bridged artificial nucleic acids developed in the lab and works in cooperation with the chemistry group.
MembersFaculty
The members of the Bioorganic Chemistry Lab consist of faculty members, Project Associate Professors and Project Assistant Professors, project researchers, doctoral, master's, and undergraduate students, international students, visiting faculty and researchers, and secretaries.As of 2026
- ProfessorSatoshi Obika
- Associate ProfessorTakao Yamaguchi
- LecturerNobumasa Hino
- LecturerTakashi Osawa
- Project Associate ProfessorRyu Nagata
- Project Assistant ProfessorMd Ariful Islam
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNA Ligase DNA Replication” Christinelmiller / CC BY-SA 4.0 (cropped)
- Chemical Modification of Nucleic Acids and Artificial Nucleic Acids: “DNA Helicase DNA Replication” Christinelmiller / CC BY-SA 4.0 (cropped)
- Therapies That Control RNA Function: “Antisense Oligonucleotide Use in ncRNA therapy” KB-OKO / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Biology Lab (Life Pharmaceutical Sciences Area)): “Gene therapy” 作者不詳 / Public domain (cropped)
- Related lab (Medicinal Synthetic Chemistry Lab (Chemical Pharmaceutical Sciences)): “Ballon bi-col 250mL” MrXandorf / CC BY-SA 4.0 (cropped)
- Related lab (Neuropharmacology Lab (Medical and Public Health Pharmaceutical Sciences)): “Muscarinic receptor M2 coupled to protein G - 6OIK” Vcilleros / CC BY-SA 4.0 (cropped)
- Related lab (Cardiovascular Drug Discovery Lab (Medical and Hygienic Pharmaceutical Sciences)): “Blood vessels-MIP” Antonino Paolo Di Giovanna / CC BY-SA 4.0 (cropped)
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