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Biological Response Regulation Lab (Life Pharmaceutical Sciences)
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A lab that studies how the immune response works, with the aim of developing therapeutic drugs.
AboutAbout the lab
Understanding the dual nature of immunity and controlling it with drugs.
The Biological Response Regulation Lab (Prof. Saitoh's lab) studies the immune response, the biological response induced against foreign substances.
While the immune response protects the body, when it is mistakenly directed against the body's own components or nutrients, it leads to autoimmune diseases and lifestyle-related diseases.
The lab focuses in particular on innate immunity, investigating the immune mechanisms that prevent infections and cancer as well as the aberrant immune responses involved in the onset of disease.
The lab also aims to develop therapeutic drugs that control the immune response.
Key terms
- Innate immunity
- The front line of biological defense, which detects foreign substances with receptors and attacks them, and can also trigger the activation of adaptive immunity.
- Organelles
- Intracellular structures, such as mitochondria, phagosomes, and the endoplasmic reticulum, that cells need to carry out their diverse functions.
- Compound library screening
- The process of selecting, from a large number of compounds, those that produce the intended effect.
NewsLab news
Prof. Saitoh's Japanese-language review article published in YAKUGAKU ZASSHI
Prof. Saitoh's Japanese-language review article published in Gout and Uric & Nucleic Acids
A doctoral student received the Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
A paper by Associate Professor Takemura and colleagues selected for features including the cover illustration of Biol Pharm Bull
A paper by a doctoral student and Associate Professor Takemura published in Biol Pharm Bull
ResearchResearch themes
The immune response eliminates foreign substances such as pathogens and cancer cells to prevent infections and cancer, but when it is mistakenly directed against the body's own components or nutrients, it leads to autoimmune diseases and lifestyle-related diseases. The lab aims to correctly understand how the immune response works and to develop drugs that control it appropriately, centering its work on the following research.
*Illustrative imageImmune responses involved in eliminating foreign substances
Organelles such as mitochondria are involved in the process by which innate immunity detects foreign substances and triggers an immune response. The lab investigates the roles organelles play in immune responses that prevent infections and cancer, and the roles intracellular degradation mechanisms play in controlling immune responses.
*Illustrative imageAberrant immune responses and the onset of disease
When the immune response is mistakenly directed against the body's own components or nutrients, it becomes a cause of diseases such as autoimmune diseases and metabolic and endocrine diseases. The lab analyzes how the immune response contributes to the onset of cancer, autoimmune diseases, lifestyle-related diseases, and allergic diseases.
*Illustrative imageDeveloping therapeutic drugs that control the immune response
Through compound library screening, the lab has found multiple compounds that control the immune response, and is working to elucidate their mechanisms of action and verify their therapeutic effects. It collaborates with other research institutions and pharmaceutical companies, aiming to develop vaccines and new anti-inflammatory and anti-allergy drugs.
MembersFaculty
The lab's members are faculty, doctoral and undergraduate students, and technical assistants.As of 2026
- ProfessorTatsuya Saitoh
- Associate ProfessorNaoki Takemura
- LecturerMitsuhiro Takahama
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratory desk” Goldmund100 / CC BY-SA 3.0 (cropped)
- Immune responses involved in eliminating foreign substances: “Macrophages undergo mitosis after ingesting a fungal cell” Carolina Coelho / CC BY-SA 4.0 (cropped)
- Aberrant immune responses and the onset of disease: “Warm autoimmune hemolytic anemia” E. Uthman, MD / CC BY-SA 2.0 (cropped)
- Developing therapeutic drugs that control the immune response: “Robot arm handles an assay plate” National Institute of Allergy and Infectious Diseases / Public domain (cropped)
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（医療・衛生薬学領域） ): “Blood vessels-MIP” Antonino Paolo Di Giovanna / CC BY-SA 4.0 (cropped) - Related lab (再生適応学分野
（生命薬学領域） ): “Skeletal muscle 400x” Alexander G. Cheroske / CC BY-SA 4.0 (cropped) - Related lab (酵素反応解析学
（研究室） ): “Cytochrome P450 aromatic O-demethylase GcoA GcoB” JMTomson / CC BY-SA 4.0 (cropped) - Related lab (臨床薬効解析学分野
（医療・衛生薬学領域） ): “CT Coronary Artery Imaging” Goleisureintl / CC BY 4.0 (cropped)
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