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Immunogenomics Lab
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The lab develops personalized cancer immunotherapy based on genomic information.
AboutAbout the lab
Toward cancer immunotherapy tailored to each patient
Keeping in mind 'research that benefits patients' and 'research that can be returned to patients,' the Immunogenomics Lab aims to realize precision medicine, which provides the optimal treatment for each individual patient.
Using data centered on genome analysis and immunogenomic analysis, the lab aims to elucidate the causes of diseases, search for biomarkers, and develop new immunotherapies.
The lab is also working on developing personalized cancer immunotherapy based on each patient's genomic and gene expression information.
The lab's website is the page of the 'Intractable Disease and Immuno-Genomics Research Project' at the National Institutes of Biomedical Innovation, Health and Nutrition.
Key terms
- Precision medicine
- Medicine that provides the optimal treatment for each individual patient
- Neoantigen
- An abnormal protein produced from a genetic mutation that serves as a 'marker' on cancer cells and a target for immune cells
- Biomarker
- An indicator within the body used to objectively measure the state of a disease, the effect of treatment, and so on
ResearchResearch themes
Using multi-omics data centered on genome analysis and immunogenomic analysis, this lab elucidates the causes of diseases and searches for biomarkers. It is also working on developing personalized cancer immunotherapy based on each patient's genomic and gene expression information.
*Illustrative imageCancer immunotherapy targeting genetic mutations
Abnormal proteins in cancer cells become neoantigens, which are markers that immune cells target. The lab develops methods that use genome analysis and bioinformatics to predict the optimal targets for each patient, and works on developing cancer vaccines and T cell-based therapies.
*Illustrative imageGenome analysis of cancer and intractable diseases
Using specimens such as patients' cancer tissue, lymph nodes, and blood, the lab performs genome analysis and immunogenomic analysis to search for biomarkers that predict the efficacy and side effects of immunotherapy. It also analyzes intractable diseases other than cancer.
MembersFaculty
The members of the Intractable Disease and Immuno-Genomics Research Project consist of a project leader, chief researchers, project researchers, visiting researchers, affiliated graduate students, trainees, technical assistants, and administrative assistants.
- Project LeaderKazuma Kiyotani
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Genome Skimming” DYCL / CC BY-SA 4.0 (cropped)
- Cancer immunotherapy targeting genetic mutations: “Adoptive T-cell therapy” Simon Caulton / CC BY-SA 3.0 (cropped)
- Genome analysis of cancer and intractable diseases: “Normal Lymph Node” Ed Uthman, MD / CC BY-SA 2.0 (cropped)
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