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Bacterial Informatics Lab
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The lab investigates the infection mechanisms of pathogenic bacteria and the bacterial microbiota using genomic information.
AboutAbout the lab
Reading pathogenic bacteria through genomic information
The Bacterial Informatics Lab studies the mechanisms by which pathogenic bacteria cause disease.
The lab says that clarifying how diseases arise reveals the molecules that should be targeted by drugs, which leads to the development of preventive and therapeutic methods.
In addition to infections caused by Streptococcus pneumoniae and Streptococcus pyogenes, the lab studies the human microbiome using genomic information and molecular biology experiments.
On the institute's website, the lab is introduced as the 'Bacterial Informatics Project' of the National Institutes of Biomedical Innovation, Health and Nutrition.
Key terms
- Pan-genome-wide association study
- An analysis that compares the entire genomes of bacterial strains to find bacterial genes that correlate with disease state
- Fulminant streptococcal infection
- An infection caused by beta-hemolytic streptococci that involves shock symptoms along with liver failure, kidney failure, and other complications. It is rare, but can occur in anyone
- Microbiome
- The communities of microorganisms living on the skin, in the mouth, in the gut, and elsewhere. Their balance is involved in promoting health and in the onset of disease
ResearchResearch themes
As infections caused by drug-resistant bacteria become a threat to the international community, this lab works to elucidate the mechanisms by which pathogenic bacteria cause disease. In addition to pathogenic bacteria, it analyzes the bacterial microbiota to identify factors involved in promoting health and worsening disease.
*Illustrative imageProgression of pneumococcal infection to severe disease
The lab investigates the mechanisms by which pneumococcal infection becomes severe, from both the bacterial side and the host side. It searches for genes that correlate with disease state using pan-genome-wide association studies of bacteria, and also compares the immune responses of young and aged hosts.
*Illustrative imageMechanisms of onset of fulminant streptococcal infection
The lab compares the whole-genome information of strains from fulminant and non-fulminant disease and investigates the bacterial mutations that correlate with the fulminant form. It is currently clarifying in detail the mutations that contribute to progression to the fulminant form, and is attempting to develop new preventive and therapeutic drugs based on the findings.
*Illustrative imageMicrobiome analysis
The lab examines in detail the microbial communities living on the skin, in the mouth, in the gut, and elsewhere, using metagenomic analysis and bacterial single-cell analysis, and searches for useful genetic resources. Knowing how far resistance genes spread provides information for preventing their expansion.
MembersFaculty
The members of the Bacterial Informatics Project consist of a project leader, researchers, project researchers, trainees and affiliated graduate students, and administrative assistants.
- Project LeaderMasaya Yamaguchi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Streptococcus pneumoniae R-phase-blood agar” Pavel Dušek, vyfotografováno s laskavým svolením zaměstnanců Ústavu imunologie a mikrobiologie 1. LF UK / CC BY 3.0 (cropped)
- Progression of pneumococcal infection to severe disease: “Streptococcus pneumoniae” Photo Credit: CDC/Janice Carr Content Providers(s): CDC/Dr. Richard Facklam / Public domain (cropped)
- Mechanisms of onset of fulminant streptococcal infection: “Streptococcus Pyogenes (Group A Strep)” NIAID / CC BY 2.0 (cropped)
- Microbiome analysis: “Gram stain of Streptococcus pneumoniae” Arnold Kaufman / CC0 (cropped)
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