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Chemical Safety Assessment Lab
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The lab researches methods for predicting and assessing the safety of chemical substances.
AboutAbout the lab
Predicting health effects from the toxicity of chemical substances
The Chemical Safety Assessment Lab collects information on the safety of chemical substances and researches methods for predicting and assessing health effects based on the results of toxicity tests.
The lab's website is that of the Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences.
For foods, drugs, tap water, cosmetics, household products, and the like to be used safely, it is necessary to set safety standard values for the chemical substances they contain and to manage them appropriately.
This research makes it possible to introduce new assessment methods into regulation and to advance the replacement of animal testing with methods that do not use laboratory animals.
The lab conducts its research in cooperation with domestic and international organizations such as the Ministry of Health, Labour and Welfare, the WHO, and the OECD.
Key terms
- Chemical Substances Control Act
- The Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. It provides for pre-market review and continuous management after products reach the market
- Positive list system
- A system that permits the use of only those substances whose safety has been evaluated. It differs from a system that specifies the substances whose use is restricted
- In silico
- An assessment method that predicts the toxicity of chemical substances by computer. Its practical operational use is called for internationally
ResearchResearch themes
In areas such as the Chemical Substances Control Act, food utensils, containers and packaging, tap water, and poisonous and deleterious substances, the lab collects and evaluates toxicity information on chemical substances. It also researches in silico toxicity assessment methods that predict toxicity by computer.
*Illustrative imageAssessment of Human Health Effects under the Chemical Substances Control Act
For the "human health effects assessment" handled by the Ministry of Health, Labour and Welfare for new and existing chemical substances, the lab drafts assessment documents and provides administrative support. Toxicity test results for existing chemical substances are published in a database.
*Illustrative imagePositive List for Food Utensils, Containers and Packaging
The lab is involved in the positive list system for food utensils, containers and packaging, working on collecting toxicity information on the substances to be included in the list and on maintaining the list. It aims for rational safety assessment based on scientific evidence.
*Illustrative imageWater Quality Risk Assessment of Tap Water
To support the setting and revision of standard values and target values for tap water, the lab collects and organizes the latest toxicity information and information on assessment methods in Japan and abroad, and provides it to the Ministry of Health, Labour and Welfare. It has also proposed short-term acceptable reference values for cases where standard values are temporarily exceeded because of a disaster or accident.
*Illustrative imageAssessment Reports for Designating Poisonous and Deleterious Substances
The Poisonous and Deleterious Substances Control Act is a law that regulates substances by designating them as poisonous or deleterious substances when they pose a high risk of health hazards, mainly due to acute toxicity. The lab prepares the assessment reports used by the expert committee of the Ministry of Health, Labour and Welfare, working to prevent health hazards.
MembersFaculty
The members of the Chemical Safety Assessment Lab consist of a division director, section heads, senior researchers, researchers, part-time staff, visiting researchers, and collaborating researchers.
- DirectorKenichi Masumura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratory chemicals” 564dude / CC BY-SA 3.0 (cropped)
- Assessment of Human Health Effects under the Chemical Substances Control Act: “Toxicology Research at FDA (NCTR )” The U.S. Food and Drug Administration / Public domain (cropped)
- Positive List for Food Utensils, Containers and Packaging: “Aluminium en plastic folie verpakkingsmateriaal - Aluminium and plastic foil food packaging - The Netherlands, May 2020” Hansmuller / CC BY-SA 4.0 (cropped)
- Water Quality Risk Assessment of Tap Water: “Tap water running into a bucket” Jidda3711 / CC BY 4.0 (cropped)
- Assessment Reports for Designating Poisonous and Deleterious Substances: “FröndenbergerHeimatstube” Enyavar / CC BY-SA 4.0 (cropped)
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