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Cancer Pathology Lab
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The lab explores the mechanisms of cancer, mainly blood cancers, through RNA and metabolism.
AboutAbout the lab
Expanding the horizons of cancer research into a new field of study.
The Cancer Pathology Lab investigates the mechanisms of blood cancers such as myelodysplastic syndromes and acute myeloid leukemia, and extends its research to solid cancers in general.
The lab seeks to understand the differences between normal stem cells and cancer stem cells, and aims at therapeutic applications that build on the vulnerabilities of cancer revealed by those differences.
From the perspectives of genomic mutations, post-transcriptional regulation, chromatin regulation, metabolic reprogramming, and cell death, the lab tackles cancer from both basic and clinical sides.
Key terms
- RNA splicing
- The process of removing unneeded parts from RNA transcribed from a gene and joining the necessary parts together.
- Selenoprotein
- An antioxidant protein containing selenocysteine, which has strong reducing activity. Twenty-five types, including GPX4, are known in humans.
- Ferroptosis
- A form of cell death that occurs in an iron-dependent manner.
ResearchResearch themes
The lab aims to find the vulnerabilities of cancer cells, from blood cancers to solid cancers, and lead them to treatment. Faculty, postdoctoral researchers, and graduate students each take charge of multiple themes, working as a team with collaborators in Japan and abroad and with technical staff.
*Illustrative imageRegulation of cancer at the RNA level
The lab studies the mechanisms by which genetic information is regulated at post-transcriptional stages, such as RNA splicing, RNA methylation, and RNA transport, in search of therapeutic targets in cancer cells. It also uses mouse models to explore the significance of the evolutionary conservation of introns.
*Illustrative imageAnalysis of poor-prognosis leukemia
Among leukemias with poor prognosis, the lab focuses on leukemia with overactive EVI1, TP53-mutated leukemia, and SETBP1-mutated leukemia. Using models that mimic human disease and drug discovery screening, it explores the vulnerabilities of cancer cells and new treatment strategies.
*Illustrative imageRegulation of hematopoiesis by BRD9
At the chromatin level, the lab studies how the bromodomain protein BRD9 regulates stem cell differentiation in normal and neoplastic hematopoiesis. It also studies the differences in its role between adult and fetal hematopoiesis, and the mechanisms by which infant leukemia develops.
*Illustrative imageFerroptosis and metabolic reprogramming
The lab investigates the accumulation of oxidative stress and lipid peroxidation with aging from the perspective of selenoproteins and ferroptosis, an iron-dependent form of cell death. It also studies the relationship with the aging of hematopoietic stem cells and the onset of MDS, as well as therapeutic strategies that induce ferroptosis in cancer cells.
MembersFaculty
The members of the Cancer Pathology Lab consist of faculty, project technical staff, research fellows, PhD and master's students, and administrative staff.As of 2026
- ProfessorDaichi Inoue
- Associate ProfessorKotaro Nishimura
- Assistant ProfessorHiromi Yamazaki
- Assistant ProfessorMasaki Nomura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Blasts on PBS Microscopy of leukemic patient blood” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Regulation of cancer at the RNA level: “Process of RNA splicing” Original: Iinaba Vector: Masumrezarock100 / CC BY-SA 4.0 (cropped)
- Analysis of poor-prognosis leukemia: “Acute Promyelocytic Leukemia, Marrow Aspirate ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Regulation of hematopoiesis by BRD9: “Hematopoietic Stem Cell (NIH BioArt 199)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Ferroptosis and metabolic reprogramming: “Ferroptosis inducers” Scheng23 / CC BY-SA 4.0 (cropped)
- Related lab (免疫細胞生物学): “2-Photon Excitation” ManuelSchottdorf / CC BY 4.0 (cropped)
- Related lab (がんゲノム情報学): “ABI 3100 16-capillary DNA sequencer - Showing the capillary array and blocks and syringes” Michael Pereckas / CC BY-SA 2.0 (cropped)
- Related lab (システム代謝学): “Mass Spectrometry Laboratory ( )” IAEA Imagebank / CC BY-SA 2.0 (cropped)
- Related lab (環境応答薬理学): “Microscopy in bloom” Saraifveiga / CC BY 4.0 (cropped)
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