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Cell Biology Lab
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The lab explores the mechanisms of the Golgi apparatus and polarized transport.

AboutAbout the lab
Aiming to elucidate the mechanisms of polarized transport
The Cell Biology Lab aims to elucidate the mechanisms of polarized transport, which is important for protein secretion in cells and for the formation and maintenance of cell polarity.
The lab investigates the structure and function of the Golgi apparatus using super-resolution microscopy and electron microscopy.
The lab also generates knockout mice lacking specific genes and analyzes how transport changes in cells and in whole organisms.
Key terms
- Golgi apparatus
- One of the organelles in a cell. It is thought to modify proteins and lipids and distribute them to their destinations.
- Polarized transport
- The directed transport of various proteins to their destinations within a polarized cell.
- Knockout mouse
- A mouse in which a specific gene has been deleted. Researchers analyze what changes the deletion causes in cells and in the whole organism.
NewsLab news
Paper featured in Proceedings of the National Academy of Sciences, with a press release issued
Paper featured in Nature Communications, with a press conference held
ResearchResearch themes
The Cell Biology Lab aims to elucidate the structure and function of the Golgi apparatus, as well as the mechanisms of polarized transport, which is important for protein secretion in cells and for the formation and maintenance of cell polarity. Its research centers on microscopic observation of the Golgi apparatus and analysis of polarized transport using knockout mice.
*Illustrative imageElucidating the Structure and Function of the Golgi Apparatus
The Golgi apparatus is an organelle thought to modify proteins and lipids and distribute them to their destinations. By tagging genes to visualize the distribution of enzymes, and using super-resolution microscopy and electron microscopy, the lab has shown that the Golgi apparatus is divided into small units that repeatedly fuse and divide.
*Illustrative imageStudying Polarized Transport with Knockout Mice
The lab studies how proteins are transported in a directed manner in polarized cells such as epithelial cells and neurons. It generates knockout mice for genes such as SNARE proteins and Rab proteins, and analyzes what changes occur in transport at the cellular and organismal levels.
MembersFaculty
Members of the Cell Biology Lab consist of faculty, a visiting associate professor, visiting researchers, external collaborators, PhD students, research assistants, and secretaries.
- ProfessorAkihiro Harada
- LecturerShinichiro Yoshimura
- Assistant ProfessorTakuya Washimi
- Assistant ProfessorJi Wu
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Scientists use a low temperature scanning electron microscope (LT-SEM) to view anatomical structures needed to identify nematodes like the Parasitorhabditis - USDA-ARS” U.S. Department of Agriculture / CC BY 2.0 (cropped)
- Elucidating the Structure and Function of the Golgi Apparatus: “Golgi apparatus -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Studying Polarized Transport with Knockout Mice: “Oral epithelium - Epithelial cells - Methylene blue dye - View 40X” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
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