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Disease Pathology Lab
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The lab explores the mechanisms behind pathological specimens by studying tumor heterogeneity.
AboutAbout the lab
Exploring the mechanisms behind pathological specimens.
The Disease Pathology Lab works on both pathological diagnosis of specimens at the University Hospital and pathology research.
For the diseases encountered in daily diagnosis, the lab imagines the mechanisms behind what can be seen and conducts research to test them.
The lab focuses on tumor heterogeneity: tumor cells that should be a single clone have different properties from cell to cell.
The lab also works on methods for observing pathological tissue with new technologies.
Key terms
- Pathological diagnosis
- Diagnosis made by observing under a microscope specimens of tissue collected from a lesion. It is involved in definitive diagnosis and in deciding treatment plans.
- Clone
- A group of cells with the same genetic information that have multiplied from a single cell.
- CUBIC
- An advanced imaging technology used in basic biology. It can depict tissue clearly in three dimensions.
NewsLab news
Research results by a PhD student published in Exp Mol Pathol.
Research results by a PhD student published in Pathol Int.
ResearchResearch themes
The pillar of the lab's research is to imagine the mechanisms behind what can be seen in the diseases encountered in pathological diagnosis, and to test them. The lab works on tumor heterogeneity and on methods for observing pathological tissue with new technologies, among other topics.
*Illustrative imageTumor heterogeneity and the search for markers
Tumor cells are in principle a single clone, but when they are dissociated, some cells can form tumors again and others cannot. Because the two types cannot be told apart by shape alone, the lab aims to find and visualize markers specific to the cells that can form tumors.
*Illustrative imageTechnology for viewing pathological tissue in 3D
The lab applies CUBIC, an advanced imaging technology used in basic biology, to histopathological diagnosis, in which specimen preparation methods have hardly changed since their foundations in the mid-1800s. In joint research with research groups at the University of Tokyo and RIKEN, the lab showed that tissue can be depicted three-dimensionally.
MembersFaculty
The members of the Disease Pathology Lab consist of faculty, hospital medical staff, graduate students, technical staff, administrative assistants, technical and administrative staff of the hospital's pathology division, invited faculty, clinical professors, clinical associate professors, and part-time lecturers.As of 2026
- ProfessorEiichi Morii
- Associate ProfessorSatoshi Nojima
- Associate ProfessorTakahiro Matsui
- Associate Professor, Endowed ChairTomomi Fujii
- Assistant Professor (Intra-Faculty Lecturer)Shinichiro Tahara
- Assistant Professor (Intra-Faculty Lecturer)Masako Kurashige
- Assistant Professor, Endowed ChairHiroki Kiyokawa
- Assistant ProfessorKansuke Kido
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Thin Hair Histology Slide” Lokeshmanikanta 22 / CC BY-SA 4.0 (cropped)
- Tumor heterogeneity and the search for markers: “Cancer stem cells model” Malymajo / CC BY-SA 3.0 (cropped)
- Technology for viewing pathological tissue in 3D: “Principle of Light Sheet Fluorescence Microscopy (LSFM)” ZEISS Microscopy / CC BY 2.0 (cropped)
- Related lab (細胞生物学): “Scientists use a low temperature scanning electron microscope (LT-SEM) to view anatomical structures needed to identify nematodes like the Parasitorhabditis - USDA-ARS” U.S. Department of Agriculture / CC BY 2.0 (cropped)
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