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Tissue Biochemistry Lab
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A lab that studies how cartilage forms, aiming for regenerative therapy and drug discovery using iPS cells.
AboutAbout the lab
Studying cartilage metabolism, cartilage pathology, and cartilage regeneration
The Tissue Biochemistry Lab studies how cartilage, the basis of the skeleton, forms, and the diseases that affect cartilage.
Cartilage includes articular cartilage and growth plate cartilage. Abnormalities of articular cartilage cause joint movement disorders, and abnormalities of growth plate cartilage cause skeletal growth disorders.
Using techniques of biochemistry, molecular biology, and histology, the lab investigates the mechanisms that regulate cartilage formation and differentiation, and attempts to elucidate the pathology of cartilage diseases.
The lab also works on new regenerative therapy for cartilage using iPS cell technology, as well as on drug discovery.
Key terms
- iPS cells
- Cells induced from body cells such as skin or blood cells. In this lab, they are differentiated into chondrocytes for use.
- Cell reprogramming
- A technology discovered in the development of iPS cells that turns cells such as skin cells into other types of cells. Direct induction without going through iPS cells is also possible.
- Skeletal dysplasia
- Diseases such as skeletal growth disorders, caused by abnormalities such as those of growth plate cartilage.
- Immunogenicity
- The property of something introduced into the body to provoke an immune response. Cartilage has low immunogenicity, and allogeneic transplantation is considered possible.
ResearchResearch themes
Based on basic research on how cartilage forms and on technology for generating chondrocytes, the lab aims to elucidate cartilage diseases and develop treatments. Because patients' cartilage is precious and cannot easily be collected for study, the lab uses technology to induce chondrocytes from cells such as skin cells.
*Illustrative imageBasic research on how cartilage forms
The lab creates genetically modified mice and studies the mechanisms of chondrocyte differentiation in the living body. It analyzes the functions of molecules involved in chondrocyte proliferation and differentiation.
*Illustrative imageTechnology for generating chondrocytes
Applying cell reprogramming technology discovered in the development of iPS cells, the lab is developing technology to induce pure chondrocytes in vitro from patients' skin cells. There are methods that go through iPS cells and methods of direct induction that bypass them.
*Illustrative imagePathology and drug discovery for skeletal dysplasia
The lab induces chondrocytes from skin samples or blood of patients with skeletal dysplasia and creates cartilage tissue equivalent to the patients' cartilage. Using this tissue, it studies how the disease arises and searches for therapeutic drugs.
*Illustrative imageRegenerative therapy for articular cartilage injury
Articular cartilage has no blood vessels and rarely repairs itself naturally when damaged, so the lab is studying how to create cartilage tissue from induced chondrocytes and transplant it to the damaged site. Cartilage made from iPS cells was also found to have low immunogenicity, and the lab is advancing the development of a procedure to create cartilage tissue from clinical-grade iPS cells.
MembersFaculty
The lab's members are faculty, researchers, graduate students, technical staff, and secretaries.
- ProfessorNoriyuki Tsumaki
- Assistant ProfessorAkihiro Yamashita
- Assistant ProfessorNanao Horike
- Assistant ProfessorTakahiro Negishi
- Assistant ProfessorNobuyuki Shima
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Stem Cell Research ( )” The U.S. Food and Drug Administration / Public domain (cropped)
- Basic research on how cartilage forms: “Cartilage hyaline1” Echinaceapallida / CC BY-SA 4.0 (cropped)
- Technology for generating chondrocytes: “CSIRO ScienceImage 1521 iPS cells in the lab” , CSIRO / CC BY 3.0 (cropped)
- Pathology and drug discovery for skeletal dysplasia: “Drug discovery cycle 2” Boghog / CC BY-SA 4.0 (cropped)
- Regenerative therapy for articular cartilage injury: “Cartilage from mouse joint” Kevin Mackenzie, University of Aberdeen / CC BY 4.0 (cropped)
- Related lab (小児科学): “Belize City Hospital Childrens' Ward 1975 - Happy colouring” Infrogmation of New Orleans / CC BY 2.0 (cropped)
- Related lab (統合薬理学): “Drop on the tip” Alexander Bogatyrev / CC BY 4.0 (cropped)
- Related lab (幹細胞生物学): “MACD187 Bone-marrow-and-blood-cells” 2441050indupranavpasupula / CC BY-SA 4.0 (cropped)
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