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Other departments in Research Institute of Environmental Medicine ›Faculties at Nagoya University ›
Yoshitaka Hayashi, Professor
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The Endocrinology and Metabolism Lab belongs to the Division of Biological Adaptation and Protection at the Research Institute of Environmental Medicine. The lab conducts research in endocrine metabolism and molecular biology using models in which the glucagon gene has been modified. Its current research topics also include the pathophysiology of malignant tumors of the endocrine system, the mechanisms by which endoderm-derived cells differentiate, and the pathophysiology of hereditary endocrine diseases. Its research keywords include endocrinology, pancreatic islets, the thyroid, diabetes, cell differentiation, and transcriptional regulation.
Tomoo Ogi, Professor
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The Development and Genetics Lab conducts research under the keyword "genome instability and disease." Genome instability disorders are intractable diseases that occur when pathways that repair or recognize DNA damage do not function normally. The lab searches for the genes that cause these diseases by combining cell-based experiments that examine DNA repair function with next-generation genome analysis, and links the results to diagnosis. At the bottom of the lab's website, the names of the Development and Genetics Division of the Research Institute of Environmental Medicine, the Department of Human Genetics and Molecular Genetics of the Graduate School of Medicine, and the Gene Analysis Division of the Genome Medicine Center at the University Hospital are listed together.
Michio Nakaya, Professor
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The Disease Regulation Lab studies myofibroblasts, which are involved in fibrosis, the hardening of tissue. Fibrosis occurs when myofibroblasts overproduce and accumulate extracellular matrix such as collagen, and it is thought to be involved in chronic diseases and the progression of cancer. Because there is no definitive treatment, the lab investigates the molecules that promote fibrosis and the properties of myofibroblasts, aiming to lay the foundation for developing new therapies. Using fibrosis of the heart and liver as examples, the lab conducts its studies with mice and cells.
Chikahide Masutani, Professor
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The Genome Dynamics Regulation Lab studies how cells respond when DNA is damaged. DNA is easily damaged. Abnormalities in the mechanisms that respond to damage make the genome unstable, which is thought to cause diseases such as cancer and premature aging. Centering on the mechanism that replicates DNA past lesions, the lab investigates how the genome is kept stable. On the lab's website, it is presented under the name "Masutani Lab."
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