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Neural Systems Lab
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A lab exploring the mechanisms of the brain and psychiatric disorders through neuronal calcium signaling.
AboutAbout the lab
Exploring brain formation and disease through calcium
The Neural Systems Lab uses calcium signaling characteristic of neurons as a clue to study the mechanisms by which the brain forms and changes, as well as the causes and pathology of psychiatric and neurological disorders that arise when these mechanisms break down.
The lab conducts basic research mainly on mice as model animals, using methods such as molecular and cell biology, calcium imaging including in vivo imaging, histology, behavioral analysis, and circuit manipulation.
Its research targets range from cultured neurons to phenomena in the brain.
The lab's website introduces it under the name "Takemoto-Kimura Lab."
Key terms
- Calcium signaling
- Changes in intracellular calcium concentration, and the series of molecular pathways that are activated in turn by calcium
- Amygdala
- A brain region involved in regulating emotions such as joy, fear, and anxiety
- In vivo
- Studying phenomena that occur inside the body of a living animal (here, in the brain), rather than in cultured cells
NewsLab news
Collaborative study clarifies the neural circuit mechanism that maintains arousal in a novel environment; paper published in PNAS
Analyzed molecular changes in the mouse amygdala that reflect chronic stress; paper published in Frontiers in Molecular Neuroscience
Developed a model mouse carrying a mutation associated with a neurodevelopmental disorder; paper published in Translational Psychiatry
ResearchResearch themes
Calcium signaling in neurons is diverse and is known to be essential for healthy brain function. Abnormalities in it have been suggested to be involved in the onset of psychiatric disorders, but the pathology is still largely unknown. Using calcium signaling characteristic of neurons as a clue, this lab studies the formation of neural circuits and the role of the amygdala in regulating emotion.
*Illustrative imageNeural circuit formation and calcium
The lab investigates the role calcium signaling plays when the neural circuits that support normal brain function are formed, and the pathology of the psychiatric disorders that arise when it is disrupted.
*Illustrative imageEmotion regulation and the amygdala
The lab investigates the role of the amygdala in regulating emotions such as joy, fear, and anxiety, using calcium signaling, a molecular pathway characteristic of neurons, as a clue.
MembersFaculty
The members of the Neural Systems Lab are faculty members, visiting researchers, technicians, technical assistants, doctoral and master's students, and research students.As of 2026
- ProfessorSayaka Takemoto-Kimura-Kimura
- LecturerShinichiro Horigane
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Close-up of a lab technitian adjusting a microscope glass slide” Shixart1985 / CC BY 2.0 (cropped)
- Neural circuit formation and calcium: “Healthy neuron (NIH BioArt 197)” Courtesy of NIAID Rose Perry-Gottschalk / Public domain (cropped)
- Emotion regulation and the amygdala: “Brain diagram hu” Mysid, User:LouisBB / CC BY-SA 2.5 (cropped)
- Related lab (システム神経薬理学分野): “Axio Imager with Colibri.2 LED Lightsource for Fluorescence Illumination ( )” ZEISS Microscopy from Germany / CC BY-SA 2.0 (cropped)
- Related lab (分子代謝医学分野): “Pipette de laboratoire sur fond blanc au Bénin 02” Adoscam / CC BY-SA 4.0 (cropped)
- Related lab (病態神経科学分野): “Shaking incubator for culture tubes” real name: Matylda Sęk pl.wiki: Cygaretka commons: Cygaretka / CC BY-SA 3.0 (cropped)
- Related lab (若手研
究者インキュベートセクション): “Microscope à fluorescence (Ifremer )” Olivier Dugornay / CC BY 4.0 (cropped)
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