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Tissue and Developmental Biology Lab
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A lab exploring how bones, cartilage, and teeth are formed.
AboutAbout the lab
Understanding how bones, cartilage, and teeth are formed.
The lab aims to understand how bones, cartilage, and teeth are formed and to gain hints for new therapies.
It also carries out neurobiological research on taste.
The lab combines histology, developmental biology, molecular biology, stem cell biology, mouse genetics, bioinformatics, and other fields without being bound by disciplinary boundaries.
In undergraduate education, the lab teaches embryology, general histology, oral histology and embryology, and dental anatomy.
Key terms
- Pluripotent stem cells
- Cells that can differentiate into any tissue and can self-renew. They include ES cells and iPS cells.
- Hedgehog signaling
- A signaling pathway involved in skeletal formation. It acts in the fate determination of bone-forming cells and in the maintenance of bone tissue.
- Taste buds
- Taste receptor organs found on the tongue and elsewhere. Taste substances bind to receptors on the cells inside.
NewsLab news
A doctoral student received the Best Award at the 21st Advanced Dental School 2026
Professor Shinsuke Ohba received the Academic Award of the Japanese Society for Bone and Mineral Research
A review on the pathology and animal models of tricho-rhino-phalangeal syndrome was published in Developmental Dynamics
A student of the School of Dentistry received the Best Award at the Student-Resident Poster session of the 43rd Annual Meeting of the Japanese Society for Bone and Mineral Research
ResearchResearch themes
The lab's basic policy is to focus on hard tissues such as bone, cartilage, and teeth, to gather fundamental knowledge about how they develop and are maintained, and to develop technologies that serve as a foundation for tissue regeneration and repair therapies. The lab also conducts neurobiological research on taste and sensation in the mouth.
*Illustrative imageCell fate determination in hard tissues and applications to regeneration
The lab investigates how the fates of bone, cartilage, and tooth cells are determined, from the perspectives of gene expression regulation and epigenome dynamics. It has also reported on developing methods to generate skeletal cells from pluripotent stem cells and on a fracture treatment using a small molecule that activates Hedgehog signaling.
*Illustrative imageThe role of the secreted protein C1qTNF3
C1qTNF3, a secreted protein found in cartilage tissue, has a structure similar to adiponectin and also circulates in the blood. The lab examines its physiological roles and its roles in disease, both at the cellular level and at the whole-animal level using genetically modified mice.
*Illustrative imageFactors that build the skeleton of the jaw, face, and limbs
The lab studies the molecular mechanisms that shape the skeleton of the jaw, face, and limbs at the whole-animal level. It has identified the transcription factors GATA3 and TRPS1, which are essential for forming the boundary between the upper and lower jaws, and KLF4, which is involved in bone marrow formation, and it is now analyzing factors that contribute to hip joint development.
*Illustrative imageNeurobiology of taste and sensation in the mouth
The lab studies the mechanisms behind the age-related decline in taste function, from genes to the whole animal. Using models such as low-zinc animals, it examines the tissue structure, neural function, and behavior of taste buds, and it also studies, at the gene level, cells in organs outside the mouth that have the same function as taste cells.
MembersFaculty
The members of the Tissue and Developmental Biology Lab consist of faculty, visiting faculty and visiting researchers, collaborating researchers within the university, graduate students, undergraduate students, and administrative assistants.As of 2026
- ProfessorShinsuke Ohba
- Associate ProfessorTakashi Maeda
- LecturerMakoto Abe
- Assistant ProfessorYuki Ikeda
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Trilineage hematopoiesis (original)” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Cell fate determination in hard tissues and applications to regeneration: “Trachemys scripta x-ray with broken leg” Rave / CC BY-SA 3.0 (cropped)
- The role of the secreted protein C1qTNF3: “Cartilage hyaline1” Echinaceapallida / CC BY-SA 4.0 (cropped)
- Factors that build the skeleton of the jaw, face, and limbs: “Black bear skull 1” Acroterion / CC BY-SA 4.0 (cropped)
- Neurobiology of taste and sensation in the mouth: “Taste bud esp” NEUROtiker / CC BY-SA 3.0 (cropped)
- Related lab (系統・神経解剖学講座): “Brain Anatomy Model ( )” YVC Biology Department / CC BY 2.0 (cropped)
- Related lab (再生歯科補綴学講座): “Implant retained bridge model” Ian Furst / CC BY-SA 3.0 (cropped)
- Related lab (微生物学講座): “Streptococcus sanguinis in Gram Staining of Culture Microscopy at a Magnification of 4000X” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (生化学講座): “Cartilage from mouse joint” Kevin Mackenzie, University of Aberdeen / CC BY 4.0 (cropped)
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