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Regenerative Prosthodontics Lab
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A prosthodontics lab that uses regenerative medicine approaches to restore the function of teeth and jaws.
AboutAbout the lab
Restoring the function of teeth and jaws through the power of regenerative medicine.
The Regenerative Prosthodontics Lab is a clinical dentistry lab that conducts research aimed at restoring oral function in patients who have lost dental or jaw tissue.
Building on advances in regenerative medicine and biomaterials, the lab pursues tissue regeneration research centered on somatic stem cells.
The core of its research is the development of new medical devices and diagnostic technologies that are grounded in biology and go beyond conventional prosthodontics.
At the Department of Oral Prosthodontics and the Oral Implant Center of the university hospital, the lab also treats patients with tooth or tissue loss that is difficult for general dental clinics to handle.
Key terms
- Mesenchymal stromal cells (MSCs)
- Cells used as the material for the bone regeneration agent. In this lab, they are used in combination with a bone graft material.
- Osseointegration
- The bonding of a dental implant to the jawbone. Poor osseointegration is a cause of implant loss.
- SNP
- Single nucleotide polymorphism. An individual difference in a single base within the genetic information.
- Myokine
- A factor secreted by muscle that acts on tissues such as bone.
NewsLab news
Received the Excellent Research Presentation Award at the 55th Annual Meeting of the Japanese Society of Oral Implantology
Received the Excellent Poster Presentation Award at the 38th Annual Meeting of the Japanese Society for Temporomandibular Joint
Received the Topic Oral Presentation Award at the 134th Annual Meeting of the Japan Prosthodontic Society
Received the Topic Oral Presentation Award at the 38th Annual Meeting of the Japanese Society for Temporomandibular Joint
ResearchResearch themes
The lab aims to restore oral function in patients who have lost dental or jaw tissue. Using biological approaches with cells, bioactive substances, and biomaterials, it conducts research from basic science toward practical application on new bone regeneration agents, artificial connective tissue, wound-healing dressings, and more. It also advances diagnostic research grounded in life science; for example, it verifies SNPs involved in the onset of temporomandibular disorders using bioinformatics and genome editing, in order to create new diagnostic indicators.
*Illustrative imageRegenerating the jawbone with a bone regeneration agent
As a treatment for extensive jawbone atrophy, the lab developed a bone regeneration agent using mesenchymal stromal cells (MSCs) and a bone graft material, and demonstrated vertical bone augmentation in an animal model. Next, it aims to build a foundation for putting jawbone regenerative medicine into practice by integrating everything from cell manufacturing to evaluation of efficacy.
*Illustrative imageThe "regenerative memory" of immunomodulatory cells
The lab is exploring ways to avoid immunogenicity, a problem in allogeneic transplantation, without genetic modification. Based on the idea that MSCs that have undergone bone regeneration retain a "memory" of immunomodulatory function, it investigates the mechanism at the molecular level, aiming to create high-performance MSC products.
*Illustrative imageInteraction between the masticatory muscles and the jawbone
The lab analyzes at the cellular and molecular level how myokines secreted by the masticatory muscles during chewing affect jawbone remodeling. Beyond understanding how the jawbone is maintained, it aims to deepen understanding of how chewing affects systemic diseases.
*Illustrative imageSearching for genes involved in implant failure
The lab comprehensively analyzes single nucleotide polymorphisms (SNPs) associated with poor osseointegration, which leads to implant loss, and examines the function of the genetic variants it finds at the organism, cellular, and molecular levels. It aims to achieve highly precise implant treatment based on risk assessment for each patient.
MembersFaculty
The members of the Regenerative Prosthodontics Lab consist of a Professor, an Associate Professor, a Lecturer, and an Assistant Professor.As of 2026
- ProfessorMasahiro Nishimura
- Associate ProfessorAtsushi Mine
- LecturerTamaki Nakano
- LecturerMasakazu Ishii
- Assistant ProfessorKazumichi Wakabayashi
- Assistant ProfessorRyota Takaoka
- Assistant ProfessorYuki Takahara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Implant retained bridge model” Ian Furst / CC BY-SA 3.0 (cropped)
- Regenerating the jawbone with a bone regeneration agent: “Jaw bone 2” Tiia Monto / CC BY-SA 4.0 (cropped)
- The "regenerative memory" of immunomodulatory cells: “MSCs D21” MFT29 / CC BY-SA 4.0 (cropped)
- Interaction between the masticatory muscles and the jawbone: “MRI showing masseter muscle and neighbors” Asaf Cygelberg / CC0 (cropped)
- Searching for genes involved in implant failure: “X-ray of root analogue dental implant two rooted left lower molar” Logicwhatelse / CC BY-SA 4.0 (cropped)
- Related lab (Tissue and Developmental Biology Lab): “Trilineage hematopoiesis (original)” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Oral Cell Biology Lab): “Yeast cells and short hyphae in Gram stain” Ajay Kumar Chaurasiya / CC0 (cropped)
- Related lab (Removable Prosthodontics and Gerodontology Lab): “Making of complete denture 06” Werneuchen / Public domain (cropped)
- Related lab (Dental Biomaterials Lab): “Single crown implant” Coronation Dental Specialty Group / CC BY-SA 3.0 (cropped)
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