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Biochemistry Lab
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A lab that explores the development and metabolism of bone, cartilage, and joints at the molecular level.
AboutAbout the lab
Studying how bones, cartilage, and joints work, from molecules to whole organisms.
The Biochemistry Lab centers its research on the development, differentiation, and metabolism of bone, cartilage, and joints.
Aiming to build a foundation for developing new treatments for bone and cartilage diseases and for bone metastasis of malignant tumors, the lab studies how bone, cartilage, and joints are regulated at the molecular, cellular, and organismal levels.
Using cell biology, molecular biology, genetic engineering, mouse genetics, and morphological analysis, the lab also creates knockout and knock-in mice with genome editing technology and examines their phenotypes.
Under the slogan "Nurturing talent that will take flight to the world," the lab is also committed to educating young researchers.
Key terms
- Endochondral ossification
- A mode of bone formation in which chondrocytes form first and bone then forms through them. Most bones, except the skull bones and some other bones, form this way.
- Intramembranous ossification
- A mode of bone formation in which bone is formed directly by osteoblasts without passing through cartilage.
- Inflammasome
- A complex formed by the assembly of proteins in response to infection or stress. It induces the secretion of inflammatory cytokines and cell death.
ResearchResearch themes
The lab aims to clarify how the development, differentiation, and metabolism of bone, cartilage, and joints are regulated at the molecular, cellular, and organismal levels, and to build a foundation for developing new treatments for bone and cartilage diseases and for bone metastasis of malignant tumors. It places intracellular signal transduction, transcription factors, and epigenetic regulation at the center of its research approach, and also uses bioinformatics techniques for next-generation sequencing analysis and mass spectrometry.
*Illustrative imageHow bone forms from cartilage
Most bones are formed by endochondral ossification, which proceeds through chondrocytes. The lab studies the regulation of Sox9, a transcription factor essential for differentiation into chondrocytes, and molecules involved in epigenetic regulation.
*Illustrative imageMechanisms and treatment strategies of joint diseases
Osteoarthritis and rheumatoid arthritis are both intractable diseases in which articular cartilage is destroyed. Using genome editing technology, the lab is identifying transcription factors and signaling molecules involved in the development and differentiation of articular chondrocytes, and is also working on drug discovery to promote cartilage regeneration and repair.
*Illustrative imageMolecular mechanisms of intramembranous ossification
The lab studies how osteoblasts arise from undifferentiated mesenchymal stem cells. It succeeded in identifying and functionally analyzing Smad5, a molecule that transmits signals of the bone morphogenetic protein BMP2, and is analyzing target molecules of the downstream transcription factors Runx2 and Osterix using knockout mice.
*Illustrative imageChronic inflammation and bone and joint diseases
How chronic inflammation and endoplasmic reticulum stress contribute to disease onset is still poorly understood. The lab aims to clarify how inflammasomes are activated and contribute to disease pathogenesis, and to use this to help elucidate the mechanisms of onset of diseases such as periodontal disease and rheumatoid arthritis.
MembersFaculty
Members of the Biochemistry Lab are introduced by position: Professor, Associate Professor, Lecturer, Assistant Professor, and Project Professor.
- ProfessorKenji Hata
- Associate ProfessorTomohiko Murakami
- LecturerMaiko Sugihara
- Assistant ProfessorKanta Wakamori
- Project ProfessorRiko Nishimura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cartilage from mouse joint” Kevin Mackenzie, University of Aberdeen / CC BY 4.0 (cropped)
- How bone forms from cartilage: “Hypertrophic Zone of Epiphyseal Plate” Robert M. Hunt / Public domain (cropped)
- Mechanisms and treatment strategies of joint diseases: “Varus Knee Osteoarthritis Xray” NP2025 / CC BY-SA 4.0 (cropped)
- Molecular mechanisms of intramembranous ossification: “Marrow Adipocytes are derived from mesenchymal stem cell (MSC) differentiation” File:Marrow Adipocytes are derived from mesenchymal stem cell (MSC) differentiation. .tif: Mstyner derivative work: Guanaco / CC BY-SA 4.0 (cropped)
- Chronic inflammation and bone and joint diseases: “Osteoarthritis and rheumatoid arthritis - Normal joint Osteoarthr -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Tissue and Developmental Biology Lab): “Trilineage hematopoiesis (original)” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Oral and Maxillofacial Oncologic Surgery Lab): “Circumcision instruments on green cloth in tray - right” Dan Bollinger / CC BY-SA 4.0 (cropped)
- Related lab (Oral Physiology Lab): “Dental tool work DVIDS264901” Petty Officer 3rd Class Jake Berenguer / Public domain (cropped)
- Related lab (Oral and Maxillofacial Surgery Lab): “Dental instruments by Roboz Tech Surgical” RobozTech / CC BY-SA 4.0 (cropped)
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