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Microbiology Lab
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The lab investigates how oral bacteria and streptococci cause disease.
AboutAbout the lab
Investigating how oral bacteria cause disease.
The Microbiology Lab studies how bacteria in the mouth, and pathogenic streptococci that enter the body through the mouth, cause disease.
Dental caries and periodontal disease, the two major dental diseases, are both bacterial infections, and bacteriological research is regarded as an important issue in dentistry.
Going beyond dentistry, the lab analyzes the mechanisms by which disease develops and carries out research that forms the basis for new treatments and preventive methods.
Key terms
- Fulminant group A streptococcal infection
- A severe disease caused by group A Streptococcus, referred to as "fulminant" or "invasive"
- Virulence factor
- A factor involved when bacteria infect a host and cause disease. Some that help bacteria attach to epithelial cells have been reported
- Streptococcus pneumoniae
- A bacterium that causes pneumonia and is also frequently isolated in otitis media in children
NewsLab news
Associate Professor Hirose received the Graduate School Dean's Award (Research) for fiscal 2025
At the Japanese Association for Oral Biology, an assistant professor received the Aichi Gakuin University 150th Anniversary Commemorative Award, and a graduate student received the Morita Excellent Presentation Award
Associate Professor Hirose received the Graduate School Dean's Award (Research) for fiscal 2024
At the Japanese Society for Bacteriology, a graduate student received a Poster Award
Professor Kawabata received the Asakawa Award from the Japanese Society for Bacteriology
ResearchResearch themes
Dental caries and periodontal disease, the two major dental diseases, are both bacterial infections. The lab analyzes the mechanisms of disease onset for oral bacteria and for pathogenic streptococci that invade the body through the mouth.
*Illustrative imageResearch on group A Streptococcus
The lab has clarified at the molecular level how the bacteria that cause fulminant group A streptococcal infection invade the body. It is now investigating how bacteria that have invaded tissue evade the human immune system, and is working to identify new virulence factors.
*Illustrative imageVirulence factors of pneumonia-causing bacteria
Much remains unknown about how pneumonia becomes severe, so the lab is identifying and analyzing the functions of virulence factors involved in the establishment of Streptococcus pneumoniae infection. Based on these findings, it is also searching for vaccine antigens.
MembersFaculty
The members of the Microbiology Lab consist of faculty members and graduate students.As of 2026
- ProfessorShigetada Kawabata
- Associate ProfessorYujiro Hirose
- Assistant ProfessorMasayuki Ono
- Assistant ProfessorEri Ikeda
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Streptococcus sanguinis in Gram Staining of Culture Microscopy at a Magnification of 4000X” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Research on group A Streptococcus: “Streptococcus pyogenes (Lancefield Group A) on Columbia Horse Blood Agar - Detail - (1)” Nathan Reading from Halesowen, UK / CC BY 2.0 (cropped)
- Virulence factors of pneumonia-causing bacteria: “Streptococcus pneumoniae - A causative bacteria of meningitis” www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Related lab (Systematic Anatomy and Neuroanatomy Lab): “Brain Anatomy Model ( )” YVC Biology Department / CC BY 2.0 (cropped)
- Related lab (Tissue and Developmental Biology Lab): “Trilineage hematopoiesis (original)” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Pharmacology Lab): “Pipette 0,5 ml nah” Lysippos / CC0 (cropped)
- Related lab (Oral and Maxillofacial Pathology Lab): “Stained microscope slide” Waughd / CC BY-SA 4.0 (cropped)
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