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Shimobayashi Lab
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The lab investigates the principles of rewinding cellular time through the mechanisms of membraneless organelles.
AboutAbout the lab
Understanding cells through the physics of molecular assembly.
Molecules inside cells spontaneously assemble to form organelles that are not enclosed by lipid membranes, and these organelles play important roles throughout the cell.
Shimobayashi Lab focuses on the statistical properties of molecules in cells, including phase separation, to uncover the roles of membraneless organelles.
In particular, the lab studies the principles of reprogramming, which turns back the time of cells, using approaches that go beyond conventional molecular biology, such as super-resolution imaging, optical control of molecular assembly, and mathematical modeling.
Key terms
- Phase separation
- A phenomenon in which molecules gather and form regions separate from their surroundings, like oil and water
- Organelle
- A small structure inside a cell that has a specific function
- Reprogramming
- Returning a cell to a less differentiated state. This is the process used to make iPS cells
- Super-resolution imaging
- An imaging technique that sees finer detail than the limit of ordinary optical microscopes
ResearchResearch themes
The findings will also contribute to the development of next-generation technologies for generating iPS cells.
*Illustrative imageObserving the dynamics of reprogramming factors
The lab succeeded in labeling reprogramming factors in iPS cells with fluorescent tags and visualizing them at super-resolution. It is now working to clarify the role that their structure and movement play in transcription.
*Illustrative imagePrinciples of nanostructures at neuronal synapses
It has long been thought that nanoscale structures exist at the sites where neurons release the vesicles that transmit information. The lab succeeded in reproducing this structure by reconstituting the proteins that form it in vitro.
MembersFaculty
- Associate ProfessorShunsuke Shimobayashi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Super Resolution Fluorescence Microscopy (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Observing the dynamics of reprogramming factors: “Fluorescent Proteins” Xiaokun / Public domain (cropped)
- Principles of nanostructures at neuronal synapses: “Synapse Illustration unlabeled-es” Synapse_Illustration2_tweaked.svg: Nrets / CC BY 4.0 (cropped)
- Related lab (Takashima Lab): “Spectrum of pluripotency in the human embryo” Ávila-González D, Portillo W, García-López G, Molina-Hernández A, Díaz-Martínez NE and Díaz NF / CC BY 4.0 (cropped)
- Related lab (Takahashi Lab): “Ribosome mRNA translation de” Matt / Public domain (cropped)
- Related lab (Woltjen Lab): “XBio illustration – Genome Editing” explorebiology / CC BY 4.0 (cropped)
- Related lab (Yamamoto Lab): “Cellular senescence” Alshaebi F, Sciortino A / CC BY 4.0 (cropped)
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